Criteria Characterizing Tumor Cells Observed in the Helicobacter Pylori- Associated-Gastric Epithelial Cells and Predicting Tumorgenesis

Abstract

Helicobacter pylori infection appears to be the most important cause of gastritis, gastric and duodenal ulcer. Biopsy specimens of gastric mucosa of patients with chronic gastritis proven by bacteriological test and endoscopy assessed the presence of organisms in lumen of numerous glands. Light and electron micrographs revealed curved organism, quite close to superficially damaged epithelial cells. Although no direct contact could be detected between the organisms and the epithelial cells yet they influenced their outlook. Changes on the microvillus surface, as well as within the epithelial cells were noticed. The most important of which are the frequent presence of pale-nuclei, type 1 nuclear pocket and nuclear inclusion in the nuclei and pusity of organelle in their cytoplasm. The observation indicated disturbed metabolism and predicting early transformation of normal cells to tumor cells.