Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations

Aliberti, Stefano; Goeminne, Pieter; O’Donnell, Anne E.; Aksamit, Timothy R.; Al-Jahdali, Hamdan; Barker, Alan F.; Blasi, Francesco; Boersma, Wim; Crichton, Megan; Soyza, Anthony De; Dimakou, Katerina; Elborn, Stuart; Feldman, Charles; Tiddens, Harm; Haworth, Charles; Hill, Adam T.; Loebinger, Michael R.; Martínez‐García, Miguel Ángel; Meerburg, Jennifer J.; Menéndez, Rosário; Morgan, Lucy; Murris, Marlène; Polverino, Eva; Ringshausen, Felix C.; Shteinberg, Michal; Sverzellati, Nicola; Tino, Gregory; Torres, Antoni; Vandendriessche, Thomas; Vendrell, Montserrat; Welte, Tobias; Wilson, Robert; Wong, Conroy; Chalmers, James D.

doi:10.1016/s2213-2600(21)00277-0

Cited by 121 publications

(136 citation statements)

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“…As the reported percentage included only those individuals diagnosed with bronchiectasis, the true prevalence remains to be further elucidated. Currently, bronchiectasis is diagnosed based on both clinical and radiological grounds (14). The marked heterogeneity in the geographic regions, time periods, diagnostic criteria (codes only vs. chest imaging), as well as study designs and settings (6)(7)(8)(9)(10)(11)(12)(13), has made the incidence and prevalence estimates of different studies varying notably (67~566 per 100,000 inhabitants, Table 1).…”

Section: Epidemiology Of Bronchiectasismentioning

confidence: 99%

Research advances and clinical management of bronchiectasis: Chinese perspective

Gao

Song

et al. 2022

ERJ Open Res

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Section: Epidemiology Of Bronchiectasismentioning

confidence: 99%

Research advances and clinical management of bronchiectasis: Chinese perspective

Gao

Song

et al. 2022

ERJ Open Res

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“…The definition of COPD is established by the Global Initiative for Obstructive Lung Disease (GOLD) as “a common, preventable and treatable disease that is characterised by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases [ 3 ]”. Recently, an international study group involving experts from Europe (EMBARC) and the USA has generated the first consensus definition of “clinically significant [bronchiectasis] BE”, including specific clinical signs/symptoms and radiological findings [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

ROSE: radiology, obstruction, symptoms and exposure – a Delphi consensus definition of the association of COPD and bronchiectasis by the EMBARC Airways Working Group

et al. 2021

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IntroductionThe coexistence of chronic obstructive pulmonary disease (COPD) and bronchiectasis (BE) seems to be common and associated with a worse prognosis than for either disease individually. However, no definition of this association exists to guide researchers and clinicians.MethodsWe conducted a Delphi survey involving expert pulmonologists and radiologists from Europe, Turkey and Israel in order to define the “COPD-BE association”.A panel of 16 experts from EMBARC selected 35 statements for the survey after reviewing scientific literature. Invited participants, selected on the basis of expertise, geographical and gender distribution, were asked to express agreement on the statements. Consensus was defined as a score of ≥6 points (scale 0 to 9) in ≥70% of answers across two scoring rounds.ResultsA-hundred-and-two (72.3%) out of 141 invited experts participated the first round. Their response rate in the second round was 81%. The final consensus definition of “COPD-BE association” was: “The coexistence of (1) specific radiological findings (abnormal bronchial dilatation, airways visible within 1 cm of pleura and/or lack of tapering sign in ≥1 pulmonary segment and in >1 lobe) with (2) an obstructive pattern on spirometry (FEV1/FVC<0.7), (3) at least two characteristic symptoms (cough, expectoration, dyspnoea, fatigue, frequent infections) and (4) current or past exposure to smoke (≥10 pack-years) or other toxic agents (biomass, etc.)”. These criteria form the acronym “ROSE” (Radiology, Obstruction, Symptoms, Exposure).ConclusionsThe Delphi process formulated a European consensus definition of “COPD-BE association”. We hope this definition will have broad applicability across clinical practice and research in the future.

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“…Although this definition may vary over time, it does ensure homogeneity of diagnosis for both clinical and research purposes. 13 …”

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“…This reflects the fact that the so-called “asymptomatic radiological bronchiectasis”, which usually includes the bronchiectasis observed in healthy individuals or in fibrotic lung diseases, does not have any clear meaning and does not require, for the moment, any type of therapeutic approach. 13 …”

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Towards a new definition of non-cystic fibrosis bronchiectasis

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Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations

Cited by 121 publications

References 34 publications

Research advances and clinical management of bronchiectasis: Chinese perspective

Research advances and clinical management of bronchiectasis: Chinese perspective

ROSE: radiology, obstruction, symptoms and exposure – a Delphi consensus definition of the association of COPD and bronchiectasis by the EMBARC Airways Working Group

Towards a new definition of non-cystic fibrosis bronchiectasis

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