CRISPR screens identify genes essential for
in vivo
virulence among proteins of hyperLOPIT-unassigned subcellular localization in
Toxoplasma
Yuta Tachibana,
Miwa Sasai,
Masahiro Yamamoto
Abstract:The research field to identify and characterize genes essential for
in vivo
virulence in
Toxoplasma gondii
has been dramatically advanced by a series of
in vivo
clustered regularly interspaced short palindromic repeats (CRISPR) screens. Although subcellular localizations of thousands of proteins were predicted by the spatial proteomic method called hyperLOPIT, those of more than 1,000 proteins remained unassigned, and their ess… Show more
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