CRISPR/Cas9 system and its applications in nervous system diseases

Jiang, Haibin; Tang, Mengyan; Xu, Zhou; Wang, Yanan; Li, Mopu; Zheng, Shuyin; Zhu, Jianghu; Lin, Zhenlang; Zhang, Min

doi:10.1016/j.gendis.2023.03.017

Cited by 4 publications

(1 citation statement)

References 149 publications

(157 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, compared to existing gene-editing instruments, this technique is far more user-friendly, affordable, and highly efficient [ 10 ]. For example, CRISPR-Cas 9 is an affordable method of treating avian viral infections in poultry by modifying the host or virus’s DNA [ 11 ], and it has a therapeutic role in neurological disorders [ 12 ]. Moreover, CRISPR-Cas 9 has more potential in various aspects of diabetes research [ 13 ] and the prevention and treatment of Alzheimer’s disease [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Advancement of animal and poultry nutrition: Harnessing the power of CRISPR-Cas genome editing technology

Mishu,

Nath,

Sohidullah

et al. 2024

J Adv Vet Anim Res

View full text Add to dashboard Cite

CRISPR-associated proteins and clustered regularly interspaced short palindromic repeats (CRISPR-Cas) technology has emerged as a groundbreaking advancement in animal and poultry nutrition to improve feed conversion efficiency, enhance disease resistance, and improve the nutritional quality of animal products. Despite significant advancements, there is a research gap in the systematic understanding and comprehensive use of the CRISPR-Cas method in animal and poultry nutrition. The purpose of this study is to elucidate the latest advancements in animal and poultry nutrition through CRISPR-Cas genome editing technology, focusing on gene manipulation in metabolism, immunity, and growth. Following preferred reporting items in meta-analysis and systematic reviews guidelines, we conducted a systematic search using several databases, including Scopus, PubMed, and Web of Science, until May 2024, and finally, we included a total of 108 articles in this study. This article explores the use of the CRISPR-Cas system in the advancement of feed additives like probiotics and enzymes, which could reduce the use of antibiotics in animal production. Furthermore, the article discusses ethical and regulatory issues related to gene editing in animal and poultry nutrition, including concerns about animal welfare, food safety, and environmental impacts. Overall, the CRISPR-Cas system holds substantial promise to overcome the challenges in modern animal agriculture. By enriching the nutritional quality of animal products, increasing disease resistance, and improving feed efficiency, it offers sustainable and cost-effective solutions that can revolutionize animal and poultry nutrition

show abstract