CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic
Escherichia coli
Liang Chen,
Gisele Peirano,
Kelly Yen
et al.
Abstract:IncF plasmids are commonly found in extra-intestinal pathogenic
Escherichia coli
(ExPEC) strains, serving as reservoirs for antimicrobial resistance (AMR) genes and virulence factors, persistently coexisting with ExPEC lineages. Multidrug-resistant (MDR) high-risk ExPEC clones, particularly ST131, ST1193, and ST410, have acquired diverse IncF plasmids over time, containing various AMR determinants, contributing significantly to their global success. However, the broader roles of these I… Show more
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