2021
DOI: 10.31219/osf.io/mc26v
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CRISPR/Cas system research has advanced significantly in biological sciences.There are still many challenges to effective delivery before efficient gene editing may be achieved

Abstract: The CRISPR/Cas system's discovery and execution offer great promise for the treatment of human illnesses and the revolutionization of plant breeding. Despite the fact that CRISPR/Cas system research is well advanced in the life sciences community, there are still considerable barriers to effective delivery that must be overcome before effective gene editing can be achieved. Consider characteristics like specificity, efficacy, and controlled expression while deciding on a plan. Due to the discovery of innovativ… Show more

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Cited by 4 publications
(4 citation statements)
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“…Impaired skin barrier function and host immunological conditions comparable to nonsyndromic ichthyoses have been linked to increased vulnerability (4,64). In response to antigens, including Candida antigens, normal lymphocyte profiles and proliferation have been documented (65). However, concerns have been expressed about immunological dysregulation and primary systemic immunodeficiency.…”
Section: Fungal Infection and Kid Syndromementioning
confidence: 99%
“…Impaired skin barrier function and host immunological conditions comparable to nonsyndromic ichthyoses have been linked to increased vulnerability (4,64). In response to antigens, including Candida antigens, normal lymphocyte profiles and proliferation have been documented (65). However, concerns have been expressed about immunological dysregulation and primary systemic immunodeficiency.…”
Section: Fungal Infection and Kid Syndromementioning
confidence: 99%
“…AGEs harm tissues in two ways: first, they modify protein structures by covalently cross-linking them, and second, they activate a number of intracellular pathways that increase the production of inflammatory cytokines and the creation of reactive oxygen species (ROS) (23). Furthermore, AGEs-RAGE interaction inhibits TGF-mediated activation of ERK1/2 and SMAD, as well as upregulating Egr-1, which stimulates RAGE transcription in COPD (67). Chronic oxidative stress, which has also been linked to COPD, is the most important regulator of AGE production.…”
Section: In Copd the Age-rage Axis And Srage Play A Rolementioning
confidence: 99%
“…The necrotic or nonfunctioning myocardium has no method of recovering and functioning properly, which has become a serious concern in the treatment of cardiac problems. Stem cell transplantation has recently been shown to enhance heart function via a paracrine impact (66,67). Many paracrine factors produced by stem cells directly mend regenerated cardiac tissue, allowing them to enable cell-free therapy in the future.…”
Section: Myocardial Infarction and Exosomesmentioning
confidence: 99%