CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy

Kong, Huimin; Yi, Ke; Mintz, Rachel L.; Wang, Bin; Xu, Yanteng; Lao, Yeh-Hsing; Tao, Yu; Li, Mingqiang

doi:10.1039/d3cc05375j

Chem. Commun.

2024

DOI: 10.1039/d3cc05375j

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CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy

Huimin Kong,

Ke Yi,

Rachel L. Mintz

et al.

Abstract: The emerging field of liquid biopsy has garnered significant interest in precision diagnostics, offering a non-invasive and repetitive method for analyzing bodily fluids to procure real-time diagnostic data. The precision...

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2024

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Cited by 3 publications

References 109 publications

(169 reference statements)

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Harnessing the power of clustered regularly interspaced short palindromic repeats (CRISPR) based microfluidics for next-generation molecular diagnostics

Kaur,

Gupta,

Chauhan

et al. 2024

Mol Biol Rep

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Harnessing the power of clustered regularly interspaced short palindromic repeats (CRISPR) based microfluidics for next-generation molecular diagnostics

Kaur,

Gupta,

Chauhan

et al. 2024

Mol Biol Rep

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Liquid biopsy applications in oral oncology: Clinical utility and future directions

Sundaram,

Sivasubramani

2024

Oral Oncology Reports

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Biomaterial-Based CRISPR/Cas9 Delivery Systems for Tumor Treatment

Li,

Chen,

Yang

et al. 2024

Biomater Res

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CRISPR/Cas9 gene editing technology is characterized by high specificity and efficiency, and has been applied to the treatment of human diseases, especially tumors involving multiple genetic modifications. However, the clinical application of CRISPR/Cas9 still faces some major challenges, the most urgent of which is the development of optimized delivery vectors. Biomaterials are currently the best choice for use in CRISPR/Cas9 delivery vectors owing to their tunability, biocompatibility, and efficiency. As research on biomaterial vectors continues to progress, hope for the application of the CRISPR/Cas9 system for clinical oncology therapy builds. In this review, we first detail the CRISPR/Cas9 system and its potential applications in tumor therapy. Then, we introduce the different delivery forms and compare the physical, viral, and non-viral vectors. In addition, we analyze the characteristics of different types of biomaterial vectors. We further review recent research progress in the use of biomaterials as vectors for CRISPR/Cas9 delivery to treat specific tumors. Finally, we summarize the shortcomings and prospects of biomaterial-based CRISPR/Cas9 delivery systems.

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CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy

Abstract: The emerging field of liquid biopsy has garnered significant interest in precision diagnostics, offering a non-invasive and repetitive method for analyzing bodily fluids to procure real-time diagnostic data. The precision...

Cited by 3 publications

References 109 publications

Harnessing the power of clustered regularly interspaced short palindromic repeats (CRISPR) based microfluidics for next-generation molecular diagnostics

Harnessing the power of clustered regularly interspaced short palindromic repeats (CRISPR) based microfluidics for next-generation molecular diagnostics

Liquid biopsy applications in oral oncology: Clinical utility and future directions

Biomaterial-Based CRISPR/Cas9 Delivery Systems for Tumor Treatment

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