CRISPR, CAR-T, and NK: Current applications and future perspectives

Khoshandam, Mohadeseh; Soltaninejad, Hossein; Hamidieh, Amir Ali; Hosseinkhani, Saman

doi:10.1016/j.gendis.2023.101121

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Metal Ions In Anti-cancer Immunity1

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2024

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Cited by 2 publications

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“…Natural killer (NK) cells originate from bone marrow stem cells, undergo two differentiation and maturation pathways in the bone marrow and thymus, and are widely distributed in the main organs. NK cells selectively kill target cells, such as viral infections or tumors, and play an important role in anti-tumor immunity ( 35 , 36 , 61 , 62 ). The ablation of either RAI1 or STIM1 in NK cells severely impairs defective store-operated Ca 2+ entry but not cytotoxic granule polarization ( 63 , 64 ).…”

Section: Metal Ions In Anti-cancer Immunitymentioning

confidence: 99%

Regulation of anti-tumor immunity by metal ion in the tumor microenvironment

Gao,

Liu,

Huang

et al. 2024

Front. Immunol.

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Metal ions play an essential role in regulating the functions of immune cells by transmitting intracellular and extracellular signals in tumor microenvironment (TME). Among these immune cells, we focused on the impact of metal ions on T cells because they can recognize and kill cancer cells and play an important role in immune-based cancer treatment. Metal ions are often used in nanomedicines for tumor immunotherapy. In this review, we discuss seven metal ions related to anti-tumor immunity, elucidate their roles in immunotherapy, and provide novel insights into tumor immunotherapy and clinical applications.

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