CRISPR-based gene expression platform for precise regulation of bladder cancer
Tianying Zhan,
Xiao Li,
Jiumin Liu
et al.
Abstract:The development of compact CRISPR systems has facilitated delivery but has concurrently reduced gene editing efficiency, thereby limiting the further utilization of CRISPR systems. Enhancing the efficiency of CRISPR systems poses a challenging task and holds significant implications for the advancement of biotechnology. In our work, we report a synthetic dual-antibody system that can stably exist in the intracellular environment, specifically inhibiting the functions of NF-κB and β-catenin. This not only eleva… Show more
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