Crise rénale sclérodermique

Teixeira, Luis; Servettaz, Amélie; Mehrenberger, Marion; Nôël, Laure-Hélène; Guillevin, Loı̈c; Mouthon, Luc

doi:10.1016/s0755-4982(06)74931-4

Cited by 17 publications

(21 citation statements)

References 32 publications

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“…In 1970 estimated prevalence was between 12 to 18% [4]. The age of onset varies between 43 and 64 [5][6][7][8], these data fit with those of the patient No. 1 who was 45 years although the case No 2 of 32 years old was younger .…”

Section: Discussionsupporting

confidence: 70%

“…Zbiti also reported a normocytic normochromic anemia with hemoglobin of 6g/dL [5]. High-dose corticosteroid therapy longer than 3 months is considered as a powerful risk factor of SRC [6,[8][9][10][11] as evidenced by case No 1 who developed a SRC after 4 months treatment with 40 mg of prednisone per day .Hypertension, usually malignant (DBP ≥ 130 mm Hg) was found in approximately 87% of patients [6,8] in its typical form. In our study 2 patients had malignant hypertension one a BP of 230 / 140mmHg and hypertensive retinopathy (case NO 1) and the other with a BP of 250 / 130mmHg and low consciousness level (case NO 2).…”

Section: Discussionmentioning

confidence: 99%

“…The histologic picture of SRC is a thrombotic microangiopathy which is seen in 43 to 56% [6,8]. A process which mainly involves small vessels [12] and manifests as myxoid intimal changes, thrombi, onion skin lesions, and/or fibrointimal proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…Prevention is the first step of SRC treatment. Although it is not clinically proven but the authors propose the use of angiotensin converting enzyme inhibitors (ACE) as a preventive measure in patients with diffuse skin [6,8,9]. The mainstay of therapy is to control blood pressure as soon as possible in the first 3 days with a goal of ≤ 120/80 mm Hg.…”

Section: Discussionmentioning

confidence: 99%

“…The mainstay of therapy is to control blood pressure as soon as possible in the first 3 days with a goal of ≤ 120/80 mm Hg. [9] Angiotensin II receptor antagonist may be less effective [6]. Half of the cases will require hemodialysis [14,15].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Scleroderma renal crisis in tropical region, two senegalese cases

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et al. 2015

Clin Case Rep Rev

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Scleroderma renal crisis (SRC) is defined as the new onset of accelerated arterial hypertension and /or rapidly progressive oliguric renal failure during the course of systemic sclerosis. It is a rare but life-threatening complication. This formerly serious complication has got a considerable brighter outlook since the introduction of angiotensin converting enzyme inhibitors (ACE) however the mortality is still remaining high. We report two cases of SRC which to our knowledge are the firsts described in Dakar. They were two women aged 45 and 32 years, one of them was previously following for systemic sclerosis. Both of them had malignant hypertension associated with rapidly progressive renal failure, the other was put under corticosteroid therapy four months before SRC occurrence. The histological and laboratory finding showed thrombotic microangiopathy. The height blood pressure returned to normal value after treatment with ACE inhibitors. The final outcome was undesirable with the death of one after two months due to the hemodialysis discontinuation and persistence of renal failure in the other.

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