Cripto in tumors and embryo development

Persico, M. Graziella; Liguori, Giovanna L.; Parisi, Silvia; D'Andrea, Daniela; Salomon, David; Minchiotti, Gabriella

doi:10.1016/s0304-419x(01)00039-7

Cited by 20 publications

(21 citation statements)

References 49 publications

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“…Of significant concern regarding ES cell replacement therapy is the risk of teratoma formation. Worth noting, Cripto is also overexpressed in a wide range of epithelial cancers, including breast, pancreatic, ovarian, and colon carcinomas, and, more recently, antibody blockade of Cripto has been shown to suppress tumor cell growth [14, 20–22]. We therefore hypothesize that inhibition of Cripto signaling in Cr −/− ES cells, in addition to directing ES cells to increased neural commitment, may block teratoma formation, thus enhancing the therapeutic potential of ES cells.…”

Section: Introductionmentioning

confidence: 99%

Cripto as a Target for Improving Embryonic Stem Cell–Based Therapy in Parkinson's Disease

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Cripto as a Target for Improving Embryonic Stem Cell–Based Therapy in Parkinson's Disease

et al. 2005

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“…Initially described as secreted molecules, members of this family are extracellular membrane proteins, anchored to the lipid bilayer through a glycosilphosphatidylinositol (GPI) moiety (Minchiotti et al 2000). Early studies of cripto were focused on its possible role in cell transformation and tumor progression (Salomon et al 1999;Persico et al 2001). Cripto expression was first found in human and mouse embryonal carcinoma cells and male teratocarcinomas and was demonstrated to be over-expressed in breast, cervical, ovarian, gastric, lung, colon and pancreatic carcinomas, in contrast to normal tissues where cripto expression was invariably absent (Strizzi et al 2005).…”

Section: Criptomentioning

confidence: 99%

Embryonic Stem Cells as a Model System to Elucidate Early Events in Cardiac Specification and Determination

Minchiotti¹,

D’Aniello²,

Ronca³

et al. 2011

Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis

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“…Early studies of cripto were focused on its possible role in cell transformation and tumor progression (Salomon et al, 1999;Persico et al, 2001). Cripto expression was first found in human and mouse EC cells and male teratocarcinomas and was demonstrated to be over-expressed in breast, cervical, ovarian, gastric, lung, colon and pancreatic carcinomas, in contrast to normal tissues where cripto expression was invariably absent (for a review see Salomon et al, 1999).…”

Section: Cripto and The Egf-cfc Familymentioning

confidence: 99%

Nodal-dependant Cripto signaling in ES cells: from stem cells to tumor biology

Minchiotti

2005

Oncogene

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Embryonic stem (ES) cells have provided a valid model to understand early events of mammalian lineage specification and differentiation, leading to important insights into the mechanisms that control embryogenesis at the molecular and cellular levels. Furthermore, ES cells have recently evoked great scientific interest as ideal candidates for the generation of tissues for transplantation therapies. In this respect, particular attention has been paid to the molecules and signaling pathways triggering ES cell differentiation. The EGF-CFC Cripto protein is a key regulator of ES cells fate. The cripto gene is expressed both in ES cells and during the early phases of embryo development, while, in the adult, it is reactivated in a wide range of epithelial cancers. This review will discuss recent findings on the molecular basis of Cripto signaling in ES cell differentiation, providing an intriguing link between stem cell and tumor biology.

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Cripto in tumors and embryo development

Cited by 20 publications

References 49 publications

Cripto as a Target for Improving Embryonic Stem Cell–Based Therapy in Parkinson's Disease

Cripto as a Target for Improving Embryonic Stem Cell–Based Therapy in Parkinson's Disease

Embryonic Stem Cells as a Model System to Elucidate Early Events in Cardiac Specification and Determination

Nodal-dependant Cripto signaling in ES cells: from stem cells to tumor biology

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