The relevance of the problem considered by the author’s team is that the tasks of preventing political corruption in the Brazilian state apparatus are connected with the solution of a huge layer of problems and issues requiring their study and analysis. The aim of this study was to study the foundations of Brazilian public policy to prevent political corruption. The methodological basis of this work was the activities of entities to prevent political corruption in Brazil. A set of General scientific and private scientific methods was used as a method. In the format of this scientific study, the authors took a number of steps that allowed them to consider the most important aspects of the problem. Including a number of high-profile political cases taking place in the context of the new Millennium in Brazil related to corruption. In the course of the study, the authors concluded that most of the subjects of anti-corruption by nature are not fully independent of political pressure, and, as a rule, have a narrow sphere of activity. In the course of the study, the authors tried to argue the thesis that in the conditions of globalization, only interdepartmental interaction of all actors in the fight against manifestations of political corruption will lead to a tangible effect. In the meantime, the necessary interaction between the subjects of the institutional corruption control machine will not be carried out, and politicians in the fight against corruption will not be effective enough. The experience of the Brazilian state policy in the sphere of combating political corruption analyzed by the author’s team can serve as a methodological basis for the preparation of various policy documents in the sphere of combating corruption in the Russian Federation.