Crimean-Congo hemorrhagic fever virus in ticks collected from imported camels in Egypt

Bendary, Hager A.; Rasslan, Fatma; Wainwright, Milton; Al‐Farraj, Saleh A.; Zaki, Aya; Abdulall, Abeer K.

doi:10.1016/j.sjbs.2021.12.043

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…CCHFV antibodies have been reported in other animals including cows (1%) ( 24 ), sheep (6.30%) cattle (3.83%), buffaloes (0.38%), and goats (1.14%) ( 42 ). Ticks have also been shown to be positive for CCHFV antibodies ( 51 , 64 , 69 ). Human cases, including healthcare workers have also been reported ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Crimean–Congo hemorrhagic fever in the Arab world: A systematic review

Perveen

Khan

2022

Front. Vet. Sci.

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Crimean-Congo hemorrhagic fever (CCHF) is an important tick-borne viral infection with a fatality rate of up to 50% during outbreaks. Crimean-Congo hemorrhagic fever virus (CCHFV) is sustained in the ecosystem in benign form through vertical and horizontal transmission cycles involving tick vectors, wildlife, and livestock. Hyalomma ticks are considered the major source of human infection. CCHF occurs most often among butchers, slaughterhouse workers, and farmworkers through infected tick bites or/and contact with blood and tissues of infected livestock. The nosocomial transmission can occur in auxiliary nurses and physicians through contact with the infected patients. The widespread distribution of CCHFV most probably occurred by ticks on migratory birds, or through international travel and trade of livestock and wildlife. During co-infections of ticks and vertebrates, reassortment among genome segments could play a significant role in generating diversity, and hence, a potential risk for the emergence of novel variants. In this systematic review, we aimed to determine the epidemiology, transmission, distribution, mortality, and clinical features of CCHF in 22 Arab countries, comprising the Arab world. Based on the analysis of 57 studies published from 1978 to 2021, we found 20 tick species that could be associated with CCHFV transmission. During the 43-year period, 321 cases of CCHF were reported from 9/22 Arab countries, Iraq, Kuwait, UAE, Saudi Arabia, Oman, Sudan, Egypt, Tunisia, and Mauritania. The mean case fatality rate was 29% during various outbreaks. Individuals working in abattoirs/slaughter houses, livestock farms, and healthcare were most at risk. Contact with blood or body secretions from infected animals and patients was the most common mode of transmission. A number of different animals, including cattle, goats, sheep, and camels were reported to be seropositive for CCHFV. The highest seroprevalence was observed in camels (29%), followed by cattle (21%), goats (15%), and sheep (14%). We discuss these results in the context of policy-making and potential preventative measures that can be implemented to reduce the burden of CCHF in the Arab world.

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Section: Resultsmentioning

confidence: 99%

Crimean–Congo hemorrhagic fever in the Arab world: A systematic review

Perveen

Khan

2022

Front. Vet. Sci.

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“… * [ 123 ] * [ 123 ] # [ 123 ] Rickettsia sp . * [ 128 , 129 , 131 ] # [ [124] , [125] , [126] , 143 ] * [ 130 ] # [ 127 ] Rickettsia africae AHF virus * [ 132 , 133 ] AHF virus CCHF virus * [ [138] , [139] , [140] ] # [ [134] , [135] , [136] , [137] ] # [ 135 ] CCHF virus LSD virus * [ 141 ] Quaranfil virus # [ 142 ] The symbol * denotes molecular detection; the symbol # denotes serologic detection; the symbol ⁑denotes studies with both serologic and molecular detection; The symbol ¶ denotes using stained blood film for detection. Abbreviations : AHF, Alkhurma haemorrhagic fever; CCHF, Crimean-Congo hemorrhagic fever; LSD, Lumpy skin disease.…”

Section: Resultsmentioning

confidence: 99%

“…dromedarii and Hy. excavatum ticks collected from imported animals in Sudan and Somalia [ [138] , [139] , [140] ].…”

Section: Resultsmentioning

confidence: 99%

“…, Rhipicephalus sanguineus Cairo, Giza, Sinai [ 128 , 131 ] Alkhurma hemorrhagic fever AHFV virus Italian tourists ND Shalateen [ 132 , 133 ]. Crimean-Congo hemorrhagic fever CCHF virus Buffaloes, camels, cattle, goats, sheep Hyalomma dromedarii, Hyalomma excavatum, Hyalomma rufipus Aswan, Cairo, Sharkia [ [134] , [135] , [136] , [137] , [138] , [139] , [140] ]. Lumpy skin disease LSD virus Cattle Rhipicephalus annulatus Benisuef [ 141 ] Not named Quaranfil virus Cattle, egrets, humans, pigeons Argas arboreus, Argas hermanni Qualyobia [ 142 ] Abbreviations : ND, Not determined; AHF, Alkhurma haemorrhagic fever; CCHF, Crimean-Congo hemorrhagic fever; LSD, Lumpy skin disease.…”

Section: Methodsmentioning

confidence: 99%

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Tick-borne diseases in Egypt: A one health perspective

Abdelbaset

Nonaka

2022

One Health

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“…CCHF disease is manifested by fever, chills, dizziness, gastrointestinal symptoms, thrombocytopenia, and hemorrhagic fever 9 . CCHF disease is primarily transmitted by ticks, 9 but cases of nosocomial infection (human to human) have been reported due to exposure with infectious blood, body fluids, or contaminated medical appliances 7 . Africa, Asia, and Europe have reported 158 nosocomial infection cases of CCHFV, and among them 92.4% cases were symptomatic with 32.4% fatality rate 10 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of highly frequent point mutations in glycoprotein C, glycoprotein N, and nucleoprotein of CCHFV

Kaushal,

Baranwal

2023

Biotech and App Biochem

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Crimean‐Congo hemorrhagic fever virus (CCHFV) is classified among top 10 priority pathogens by World Health Organization. CCHFV belongs to Bunyaviridae family and negative sense ssRNA genome composed of three RNA segments: L, M, and S. RNA viruses show higher mutation rate as compared to DNA viruses. To gain deeper understanding of impact of point mutations in CCHFV M and S segment, mutation profiling, homology modeling, and molecular dynamic (MD) simulation were performed. Structural glycoproteins (glycoprotein C [Gc] and glycoprotein N [Gn]) of CCHFV are important for host–virus interaction and genome packaging, whereas CCHFV nucleoprotein (NP) is crucial for viral replication. Hence, current study is focused on evaluation of eight mutations in structural glycoproteins (Gc: 7 and Gn: 1) of M segment and seven mutations in NP of S segment. All these mutations were highly frequent, with mutation frequency between 0.81 and 1.0 and found to be persistent in the recent strains of CCHFV. Solubility analysis predicted that selected point mutations reduce solubility of Gc protein and increase solubility of Gn and NP proteins. MD simulation study deciphered that A1046V and G1158E in Gc protein, I778T in Gn protein, and H195R in NP protein displayed large deviation and fluctuation, and affected intramolecular interactions. In conclusion, we observed that point mutations could impact structure, stability, and host–virus interaction of protein, and might lead to evolution of new strains for better survival and drug resistance.

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Crimean-Congo hemorrhagic fever virus in ticks collected from imported camels in Egypt

Cited by 12 publications

References 30 publications

Crimean–Congo hemorrhagic fever in the Arab world: A systematic review

Crimean–Congo hemorrhagic fever in the Arab world: A systematic review

Tick-borne diseases in Egypt: A one health perspective

Analysis of highly frequent point mutations in glycoprotein C, glycoprotein N, and nucleoprotein of CCHFV

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