Crimean-Congo Hemorrhagic Fever

Gök, Şebnem Eren

doi:10.5222/otd.2016.013

Cited by 1 publication

(5 citation statements)

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“…Symptoms are not expected to manifest during this period. The pre-hemorrhagic stage begins after the incubation period and lasts 4-5 days, followed by the hemorrhagic stage, during which the patient develops bleedingrelated symptoms [2,12]. In the present study, it was found that patients began to exhibit symptoms three days after tick removal, and non-survivors had a delayed admission to the emergency department.…”

Section: Discussionmentioning

confidence: 42%

“…Therefore, we attribute some of the patients' death to their inability to combat increased viral loads, bleeding, sepsis and shock. Some studies reported that fever observed during the pre-hemorrhagic period was the most common symptom, followed by asthenia, headache, anorexia and myalgia [7,10,12]. During the prehemorrhagic period, fever rises suddenly and can reach 40°C [12].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies reported that fever observed during the pre-hemorrhagic period was the most common symptom, followed by asthenia, headache, anorexia and myalgia [7,10,12]. During the prehemorrhagic period, fever rises suddenly and can reach 40°C [12]. Hasanoğlu et al [7] reported no relationship between high fever and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The hemorrhagic stage of CCHF results in either recovery or death. Bradycardia and hypotension may develop during this period because of sepsis, septic shock and hemorrhage [12]. Ahmeti et al [1] reported that bradycardia and blood pressure played no role in determining the clinical course.…”

Section: Discussionmentioning

confidence: 99%

“…The tendency for bleeding increases in patients with CCHF and extensive bleeding occurs especially in subcutaneous tissues; additionally, epistaxis, gingival bleeding, hematuria, hematemesis, vaginal bleeding and bleeding occur in internal organs [3,14,15]. Gök et al [12] reported that hematuria, hematemesis, hematochezia, melena and vaginal bleeding were common findings in patients with CCHF, and bleeding in the lungs, brain and peritoneum were rarely observed. Saksida et al [9] reported bleeding in all patients with a severe clinical course or fatal outcome.…”

Section: Discussionmentioning

confidence: 99%

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Factors affecting mortality in Crimean-Congo hemorrhagic fever

Kavak¹,

Gürbüz²

2019

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Crimean-Congo hemorrhagic fever is a viral disease that is transmitted by infected ticks and has high mortality.We aim to determine the factors affecting mortality in patients with Crimean-Congo hemorrhagic fever (CCHF). Methods: Age, gender, number of ticks, tick removal procedures, tick location, time to hospital admission, symptoms, physical examination findings, vital signs, laboratory parameters and factors affecting mortality were evaluated. The study was designed as a retrospective cohort study. Results: The median age of the 172 patients was 46 (range, 18-78) years, and 73.8% of the patients were men. The mortality rate was high in patients with delayed time to hospital admission, those who were bitten on the head and neck region, those who had a high number of tick bites, those who had removed the tick themselves or had the tick removed by a relative and those who had impaired consciousness (P=0.001, P<0.001, P<0.001, P<0.001 and P=0.002, respectively). Bleeding was detected in 87.2% of cases. The frequency of ecchymosis, pleural effusion, hematuria, hematemesis and melena occurrence was high in non-survivors (P<0.001, P<0.001, P<0.001, P=0.006 and P=0.006, respectively). Fever and heart rate were significantly higher, systolic and diastolic blood pressure was significantly lower in non-survivors (P<0.001, P<0.001, P=0.006 and P<0.001, respectively). Additionally, the white blood cell (WBC) count, international normalized ratio (INR), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly higher and platelet count were significantly lower in non-survivors (P<0.001 for all). Conclusion: We found that in patients with CCHF, bleeding was a major factor associated with mortality. Factors such as a number of ticks, the number of people removing the ticks and tick location were found to affect mortality. We believe that blood tests and vital parameters can be used to predict mortality in patients with CCHF. Öz Amaç: Kırım kongo kanamalı ateşi enfekte kenelerle bulaşan ve yüksek mortaliteye sahip viral bir hastalıktır. Kırım Kongo Kanamalı Ateşi (KKKA) hastalarında mortalite üzerinde etkili faktörleri belirlemeyi amaçladık. Yöntemler: Hastaların yaş, cinsiyet, kene teması, kene sayısı, kenenin kim tarafından çıkarıldığı, kenenin vücuttaki lokalizasyonu, hastaneye başvuru süresi, semptomları, fizik muayene ve vital bulguları, laboratuvar parametreleri ve mortaliteye etki eden faktörler değerlendirildi. Çalışma retrospektif kohort olarak dizayn edildi. Bulgular: 172 hastanın yaş ortancası 46 (18-78) yıl olup, olguların %73,8'i erkekti. Hastaneye başvurusu geç olan, baş ve boyun bölgesinden ısırılmış olan, ısıran kene sayısı fazl...

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Section: Discussionmentioning

confidence: 42%