Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures

Bakır, Mehmet; Uğurlu, Mehmet; Dokuzoğuz, Başak; Bodur, Hürrem; Taşyaran, Mehmet A.; Vahaboğlu, Haluk

doi:10.1099/jmm.0.45865-0

Cited by 180 publications

(191 citation statements)

References 14 publications

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“…However, we used parameters measured on the first day of admission to predict mortality. Bakir et al reported that INR, AST, LDH, and CK were higher in patients who died (28). In their study, serum ChT activities were significantly lower in patients with fatal CCHF compared with non-fatal CCHF and healthy controls.…”

Section: Discussionmentioning

confidence: 76%

Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Kurt

Çaycı

Öngürü

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mortality. Methods: ChT activities on the first day of hospitalization were analyzed in serum from 46 patients with CCHF and 36 healthy controls. Serum ChT activities and other clinical and laboratory parameters for patients with non-fatal and fatal CCHF were compared. Results: The median ChT activity was increased in all patients with CCHF w189.9 (134.8-246.6) nmol/mL/hx. The median ChT activity in the non-fatal CCHF group w220.2 (180.6-290.1) nmol/mL/hx was higher compared with the fatal CCHF group w29.2 (16.5-45.7) nmol/mL/hx (p-0.001). In univariate analysis, platelet count, lactate dehydrogenase (LDH), and activated partial thromboplastin time were associated with mortality. Conclusions: This is the first study investigating the association of serum ChT enzyme activity with mortality from CCHF. This study suggested that relatively low ChT enzyme activities may be a prognostic marker in patients with CCHF. Clin Chem Lab Med 2009;47:1543-7.

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Section: Discussionmentioning

confidence: 76%

Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Kurt

Çaycı

Öngürü

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…KKKA virüsü, Bunyavirüs familyas›n›n Nairovirüs genusunda ve hemorajik hummalara neden olan zoonotik orjinli bir RNA virüsüdür (4,5). ‹lk kez 1944 y›l› yaz aylar›nda K›r›m/Rusya'da, daha sonra 1956 y›l›nda Kongo/Afrika 'da izole edilmifltir (6).1967 y›l›nda Simpson ve ark.…”

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“…Ege bölgesinde KKKA virüsüne karfl› oluflmufl antikorlar saptanm›flt›r. Ancak bunlar›n titrelerinin çok düflük olmas›, virusun insidans› hakk›nda kesin bir yarg›ya var›lmas›na engel olmaktad›r (4,5). …”

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Kırım Kongo Kanamalı Ateşi Olgularında Postmortem İncelemelerde Enfeksiyondan Korunma

Keten¹,

Tümer²,

Odabaşı³

et al. 2008

Bull Leg Med

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Posmortem incelemeler uygun koşullarda yapılmadığı takdirde adli tıp çalışanları ve çevre için tehlikeli sonuçlar doğurması açısından önem taşımaktadır. Ülkemizde de son yıllarda Kırım Kongo Kanamalı Ateşi hastalığı ve bu hastalık nedeniyle meydana gelen ölüm sıklığı giderek artmaktadır. Çalışmamızda viral bulaşma riski yüksek olan Kırım Kongo Kanamalı Ateşi olgularına yapılan postmortem adli tıbbi incelemelerde dikkat edilmesi gereken hususlara vurgu yapılmıştır.Anahtar kelimeler: Otopsi, Kırım Kongo Kanamalı Ateşi, korunma

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“…This disease can be mild or mortal (4), and the early signs typically include fever, tachypnoea, hypotension, relative bradycardia, pharyngitis and sometimes conjunctivitis. The early stage of this disease is called the prehaemorrhagic phase, which is characterized by elevated liver enzymes, an increased bleeding duration and thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Findings of Crimean-Congo Hemorrhagic Fever: a Study of 269 Cases

et al. 2018

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A c c e p t e d M a n u s c r i p t 2 SummaryCrimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease. We aimed here in this study to investigate the cutaneous manifestations of CCHF and reveal their associations with fatality. Two hundred and sixty-nine patients diagnosed with CCHF were recorded. Skin findings were seen in 170 (63.1%) patients. A facial rash was most common cutaneous finding (82 (30.4%)). In the severe cases, haemorrhagic cutaneous manifestations (petechiae and ecchymoses) were recognised. A statistically significant correlation was obtained between the cutaneous manifestations and fatality, and it was determined that there was a strong positive correlation between the fatality and ecchymosis (r=567, p<0.001). In addition, a logistic regression analysis was performed, and death occurred 4.69 times more in those with skin signs than in those without. We hypothesize that CCHF patients with ecchymosis are at the highest risk, and that the cutaneous findings can contribute the prognosis of CCHF.A c c e p t e d M a n u s c r i p t 3

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Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures

Cited by 180 publications

References 14 publications

Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Kırım Kongo Kanamalı Ateşi Olgularında Postmortem İncelemelerde Enfeksiyondan Korunma

Cutaneous Findings of Crimean-Congo Hemorrhagic Fever: a Study of 269 Cases

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