CRHBP polymorphisms predict chronic pain development following motor vehicle collision

Linnstaedt, Sarah D.; Bortsov, Andrey V.; Soward, April C.; Swor, Robert A.; Peak, David A.; Jones, J. Stephen; Rathlev, Niels K.; Lee, Dong Hoon; Domeier, Robert M.; Hendry, Phyllis L.; McLean, Samuel A.

doi:10.1097/j.pain.0000000000000374

Cited by 22 publications

(11 citation statements)

References 58 publications

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“…Although HBV infection was demonstrated to be associated with CRHBP expression (P=0.020), the molecular mechanism behind downregulation of CRHBP following HBV infection remains uncharacterized. Previous research suggests that CRBHP expression was decreased following long-term stimulation by HBV ( 13 , 25 , 26 ), and that hypermethylation of the CRHBP gene caused its downregulation ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma

Xia

Wang

et al. 2018

Oncol Lett

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Corticotropin releasing hormone binding protein (CRHBP) mediates the reaction between corticotropin releasing hormone (CRH) and corticotropin releasing hormone receptors (CRHRs). It is expressed in a number of organs, and the expression of CRHBP is associated with tumorigenesis and cancer progression. The aim of the present study was to investigate CRHBP expression levels in hepatocellular carcinoma (HCC) and its association with patient clinicopathological characteristics as well as prognosis. The expression of CRHBP was examined by immunohistochemistry in 169 HCC tissues and 151 adjacent non-tumorous tissues. The results were validated by western blotting using patient tissues and liver cancer cell lines. The association of CRHBP expression with clinicopathological patient characteristics and survival rate was analyzed statistically. Expression of CRHBP was detected in 142/151 (94.0%) non-tumorous liver tissues, and 84/169 (49.7%) HCC tissues (P<0.001). The expression of CRHBP was negatively associated with tumor size (P=0.013), Edmondson Grade (P=0.002), hepatitis B virus antigen (P=0.020), and α-fetoprotein levels (P=0.014). Patients exhibiting low CRHBP expression were associated with shorter survival time compared with those exhibiting high CRHBP expression (P=0.012). The results of western blotting analysis suggest that reduced CRHBP expression is frequently observable in patients with HCC. Low CRHBP expression in HCC tissues may be a predictor of clinical prognosis and a potential therapeutic target for HCC.

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Section: Discussionmentioning

confidence: 99%

Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma

Xia

Wang

et al. 2018

Oncol Lett

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“…Finally, other risk factors should be considered such as the emotional learning circuits of the brain [40], genetic phenomena [50], and properties of the cerebral white matter [51].…”

Section: Discussionmentioning

confidence: 99%

Chronic Pain following Chest Trauma: Prevalence, Associated Factors, and Psychosocial Impact

Kahloul

Kacem

Sboui

et al. 2020

Pain Research and Management

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Background. Chronic pain (CP) is a real public health concern. It is a common cause of poor quality of life and workplace absenteeism. It is well studied in many medical and surgical fields. However, only few data are available as regards to its occurrence in trauma patients. Purpose. To assess the prevalence, associated factors, and psychosocial impact of CP following chest trauma. Methods. This is an observational, descriptive, and analytic cross-sectional study performed in a Tunisian department of anesthesia and intensive care over a two-month period. Adult patients admitted one year ago for isolated chest trauma were enrolled. Data were collected by a phone interview. Studied variables were sociodemographic characteristics, traumatic injuries and their management, the occurrence of CP, and its psychosocial impact. CP was diagnosed by the Brief Pain Inventory (BPI) considering an evolution period of at least 3 months. Its impact was assessed by the BPI and the Posttraumatic stress disorder Checklist Scale (PCLS). Results. Fifty-four patients were included in the study. The prevalence of CP was 79.6%. The average CP intensity was 3.18 ± 1.4. It was neuropathic in 90.7%. Its main associated factors were pleural effusion (p=0.016), time to ICU admission (p=0.05), and posttraumatic stress disorders (p=0.017). After a multivaried analysis, only pleural effusion was associated with CP (p=0.01, OR = 6.9 CI 95% [1.2–37.3]). Probable or very likely PTSDs were noted, respectively, in 10 and 9 cases. Regarding the psychosocial impact of CP, the most commonly affected dimensions were general activity, work, sleep, and mood. Conclusion. CP following chest trauma is frequent and severe requiring preventive measures such as high risk patients screening, better management of acute pain, and a multidisciplinary approach for patients with diagnosed CP.

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“…Level of education, pain intensity at hospital admission, and eligibility for disability compensation are factors that could potentially increase the discriminative power of our model, and their impact should be studied prospectively. Furthermore, individual factors such as properties of the brain's emotional learning circuitry [ 28 ], corticotropin-releasing hormone binding protein (CRHBP) gene polymorphisms [ 29 ], and brain's white matter structural properties [ 30 ] have been recently proposed as predictors of development of chronic pain but infer more invasive and costly investigations.…”

Section: Discussionmentioning

confidence: 99%

Early Factors Associated with the Development of Chronic Pain in Trauma Patients

Daoust

Paquet

Moore

et al. 2018

Pain Research and Management

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Objective To identify factors, available at the time of trauma admission, associated with the development of chronic pain to allow testing of preventive approaches. Methods In a retrospective observational cohort study, we included all patients ≥ 18 years old admitted for injury in 57 adult trauma centers in the province of Quebec (Canada) between 2004 and 2014. Chronic pain was defined as follows: treated in a chronic pain clinic, diagnosed with chronic pain, or received at least 2 prescriptions of chronic pain medications 3 to 12 months postinjury. Results A total of 95,134 patients were retained for analysis. Mean age was 59.8 years (±21.7), and 52% were men. The causes of trauma were falls (63%) and motor vehicle accidents (22%). We identified 14,518 patients (15.3%; 95% CI: 15.1–15.5) who developed chronic pain. After controlling for confounding factors, the variables associated with chronic pain were spinal cord injury (OR = 3.9; 95% CI: 3.4–4.6), disc-vertebra trauma (OR = 1.6; 95% CI: 1.5–1.7), history of alcoholism (OR = 1.4; 95% CI: 1.2–1.7), history of anxiety (OR = 1.4; 95% CI: 1.2–1.5), history of depression (OR = 1.3; 95% CI: 1.1–1.4), and being female (OR = 1.3; 95% CI: 1.2–1.3). The area under the receiving operating characteristic curve derived from the model was 0.80. Conclusions We identified risk factors present on hospital admission that can predict trauma patients who will develop chronic pain. These factors should be prospectively validated.

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CRHBP polymorphisms predict chronic pain development following motor vehicle collision

Cited by 22 publications

References 58 publications

Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma

Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma

Chronic Pain following Chest Trauma: Prevalence, Associated Factors, and Psychosocial Impact

Early Factors Associated with the Development of Chronic Pain in Trauma Patients

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