CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission

Li, Yijia; Han, Yang; Xie, Jing; Gu, Lijun; Li, Wenjuan; Wang, Huanling; Lv, Wei; Song, Xiaojing; Li, Yanling; Routy, Jean‐Pierre; Ishida, Takeshi; Iwamoto, Aikichi; Li, Taisheng

doi:10.1097/qad.0000000000000125

Cited by 82 publications

(99 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The subtype distribution in our study was 53.5% CRF01_AE, 14.9% B, 27.2% CRF07_BC/CRF08_BC and 4.4% other subtypes, which was consistent with previous reports 17, 18 , indicating that recombinant forms of the virus might be on the rise worldwide, which have already been associated with faster disease progression as seen in Cuba 19 and Brazil 20 . Most importantly, our study demonstrated that CRF01_AE is associated with faster HIV/AIDS progression, which is in agreement with a previous study conducted in China 14 . In another study, Ng et al .…”

Section: Discussionsupporting

confidence: 93%

“…A systematic review and meta-analysis conducted in China showed that the pooled prevalence of CRF01_AE, subtype B, CRF07_BC, CRF08_BC, and subtype C was 44.54% (95% CI 40.81–48.30), 18.31% (95% CI 14.71–22.17), 16.45% (95% CI 13.82–19.25), 2.55% (95% CI 1.56–3.73), and 0.37% (95% CI 0.11–0.72), respectively 13 . Notably, the median time from the estimated date of seroconversion to the development of AIDS in the Chinese HIV-1 population was shorter compared with that in other countries 14–16 . Thus, understanding the factors that affect HIV/AIDS progression is vitally important for personalized disease management and clinical counselling.…”

Section: Introductionmentioning

confidence: 84%

“…In our study, no significant relationship between transmission route and HIV-1 progression was observed ( P = 0.486); this finding is inconsistent with a previous study conducted in China by Li et al ., which revealed that the transmission route in MSM subjects is an independent risk factor for the progression of HIV infection to AIDS 14 . There are several possible reasons for the difference in our results.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China

Chu

Zhang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequence was amplified to ascertain the HIV-1 subtype. A Cox proportional hazards regression model was used to estimate the factors associated with HIV/AIDS progression. The median follow-up time for all 114 subjects was 26.70 months (IQR: 18.50-41.47), while the median progression time of the 38 progressed subjects was 24.80 months (IQR: 14.13-34.38). Overall, the CRF01_AE subtype was correlated with a significant risk of accelerated progression compared to non-CRF01_AE subtypes (HR = 3.14, 95%CI: 1.39-7.08, P = 0.006). In addition, a lower CD4 count (350-499) at baseline was associated with a risk of accelerated HIV/AIDS progression compared to higher CD4 count (≥500) (HR = 4.38, 95%CI: 1.95-9.82, P < 0.001). Furthermore, interaction analyses showed that HIV-1 subtypes interacted multiplicatively with transmission routes or CD4 count at baseline to contribute to HIV/AIDS progression (P = 0.023 and P < 0.001, respectively). In conclusion, the CRF01_AE subtype and a lower CD4 count at baseline tend to be associated with the faster progression of HIV/AIDS. Understanding the factors affecting HIV/AIDS progression is crucial for developing personalized management and clinical counselling strategies.Acquired immunodeficiency syndrome (AIDS) has been a major public health threat since its discovery in the United States in 1981. In general, the progression from human immunodeficiency virus (HIV) infection to AIDS development takes approximately 8-10 years 1 ; however, this duration varies among individuals. Multiple factors have been found to contribute to the progression of HIV-1 infection, such as immunological, virological and host genetic factors [2][3][4][5][6] . In particular, the emergence of RNA sequencing technologies has provided a means for analysing the association between virological factors and HIV/AIDS progression.The HIV-1 subtype has been associated with HIV/AIDS progression and has attracted much interest among researchers [7][8][9][10][11] . Unfortunately, no consensus has been reached in studies exploring the association between subtype and disease progression. Studies conducted in Tanzania and Uganda have suggested that subtype D is correlated with faster rates of CD4+ T-cell decline and disease progression than those observed in other subtypes and recombinant forms of the virus 7,8 . However, a retrospective cohort study conducted during 1996 and 2007 revealed that Africans infected with B clade HIV-1 suffered from faster rates of HIV/AIDS progression compared with those infected with non-B clade subtypes 10 . Furthermore, a meta-analysis demonstrated that the trend of HIV/AIDS progression among different HIV-1 subtypes in a descending order was subtype C > D > AE > G > A 9 . Though numerous prophylactic measures against HIV have been effectively employed in China 12 , they have not been able t...

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China

Chu

Zhang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Due to the association between X4/DM viruses and accelerated disease progression, [13,14] patients with X4/DM viruses are at higher risk of faster CD4+ cell count decline and deterioration of immune status in early stage of infection. Recently, a severe loss of CD4+ T cell count among CRF01_AE-infected patients was observed in China, [12,40] which might be ascribed to transmission of X4/DM viruses.…”

Section: Discussionmentioning

confidence: 99%

Coreceptor usage of Chinese HIV-1 and impact of X4/DM transmission clusters among recently infected men who have sex with men

Zhu

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…The predominant HIV-1 subtype in our sample set was CRF01_AE, which is mainly transmitted through sexual routes and has the characteristics of faster clinical progression than other subtypes (Li et al 2014). All of these factors support the importance to initiate ART early as a preventative method in Guangxi serodiscordant couples to reduce intra-family sexual transmission.…”

Section: Discussionmentioning

confidence: 99%

Molecular linkage tracing of HIV-1 transmission events in seroconcordant couples in Guangxi Province, Southeastern China

Wang

Tang

et al. 2016

SpringerPlus

Self Cite

View full text Add to dashboard Cite

BackgroundGuangxi Province in Southeastern China has one of the highest HIV-1 infection and transmission rates in stable couples. However, the mode of transmission at the molecular level has seldom been reported amongst this group. It is important to investigate this issue to support the treatment-as-prevention approach and for efficient interventions.MethodsHIV-1 subgenomic regions (1.2 kb of pol and a 660-bp env C2V5 fragment) were sequenced in 42 couples. A couple linkage assessment was performed by phylogenetic analysis of sequences and Bayesian analysis of genetic distances. A subset of pairs was selected for single-genome amplification.ResultsThirty-five pairs (83.3 %, 35/42) were identified as linked, 3 pairs (7.1 %, 3/42) were identified as indeterminate, and 4 pairs (9.5 %) were identified as unlinked. The predominant intra-couple-transmitted HIV-1 subtype was CRF01_AE (80 %, 28/35). The median genetic distance of linked couples was 0.5 %.ConclusionThe majority of HIV-1 transmission events in this study occurred within the partnership, and the predominant HIV-1 subtype was CRF01_AE. Further research on the mode of HIV transmission in other locations is needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-3578-2) contains supplementary material, which is available to authorized users.

show abstract

CRF01_AE subtype is associated with X4 tropism and fast HIV progression in Chinese patients infected through sexual transmission

Cited by 82 publications

References 34 publications

HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China

HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China

Coreceptor usage of Chinese HIV-1 and impact of X4/DM transmission clusters among recently infected men who have sex with men

Molecular linkage tracing of HIV-1 transmission events in seroconcordant couples in Guangxi Province, Southeastern China

Contact Info

Product

Resources

About