CRF-receptor 1 blockade attenuates acute posttraumatic hyperglycemia in rats1

Hager, Peter; Hagman, Beth; Wikström, Ann–Charlotte; Strömmer, Lisa

doi:10.1016/j.jss.2004.01.012

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…We have previously shown that intestinal resection in rats causes a pathological response to a dexamethasone-suppression test 2 h after surgery [27]. The present study extended this observation by showing that hypothalamic-pituitaryadrenal axis function is attenuated for at least 12 h after surgery.…”

Section: Discussionsupporting

confidence: 81%

An Experimental Model of Intestinal Resection and Compensated Non-Hypotensive Blood Loss

Hager

Permert

Strömmer

2009

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 81%

An Experimental Model of Intestinal Resection and Compensated Non-Hypotensive Blood Loss

Hager

Permert

Strömmer

2009

Journal of Surgical Research

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“…By controlling blood glucose levels, body metabolism might be adjusted, which would be of benefit (van den Berghe et al, 2001). Other therapy programs, such as C peptide, corticotrophin releasing factor, and so on, might also prove to be beneficial in the future (Hager et al, 2004;Kimura, 2005).…”

Section: Discussionmentioning

confidence: 99%

Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients

et al. 2014

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ABSTRACT. Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If blood glucose was more than 11.1 mM, a GHb test was followed within 24 h. All patients were followed up for 28 days. According to diabetes mellitus (DM) history, GHb value, and outcome of follow-up, patients were divided into different groups, and mortality rates were calculated, respectively. Hyperglycemia was found in 67.44% (437/648) of patients, and 51.49% (225/437) and 48.51% (212/437) had normal and elevated GHb levels, respectively. At the end of the follow-up period, 14 of the normal GHb patients and 32 of the elevated GHb patients died (6.22 and 15.09%, respectively). In the normal GHb group, 53 had a DM history, 23 were newly diagnosed with DM, and 149 had hospital- 7007Prognostic and assessment value of hyperglycemia ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 7006-7012 (2014) related hyperglycemia (HRH); the mortality rates were 11.32% (6/53), 8.70% (2/23), and 4.03% (6/149), respectively. In the elevated GHb group, 114 had a DM history, 83 were newly diagnosed with DM, and 15 had HRH; the mortality rates were 13.16% (15/114), 19.27% (16/83), and 6.67% (1/15), respectively. Hyperglycemia and GHb might play important roles in the prognosis and assessment for critical patients, and the prognosis would vary according to the different causes of hyperglycemia.

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“…This implies that the general stress associated with surgery can affect the neuroendocrine control of the reproductive axis and lead to amenorrhea. In fact, elevated levels of glucocorticoids and hyperglycemia are common consequences of activation of the HPA axis secondary to surgical interventions (Hager et al ., 2004; Hager et al ., 2009). Desborough (Desborough, 2000) suggests that surgery is one of the most potent activators of adrenocorticotrophin and cortisol release.…”

Section: Discussionmentioning

confidence: 99%

“…Characterizing the estrous cycle by cell counts is a rather sensitive measure (Goldman, Cooper, et al, 2007) but is subject to change by several environmental stressors such as chronic restraint and immobilization, varied temperature and light, electrical shock, and noise (Gonzalez, Rodriguez Echandia, Cabrera, & Foscolo, 1994). Because an experimentally induced injury is a rather invasive procedure capable of inducing a stress response (Hager, Hagman, Wikstrom, & Strommer, 2004), it remains unknown if the aberrant estrous cycle after an experimental SCI (Hubscher et al, 2006) is a result of a direct impact of the injury on the spinal cord or due to the presence of general stress associated with a surgical intervention. We assessed estrous cyclicality in female rodents after a variety of surgical interventions, that is, implantation of EMG wires into selected hind limb muscles, hemisection of the spinal cord, and injections of tracer dyes into the spinal cord to address this issue.…”

mentioning

confidence: 99%

Rodent estrous cycle response to incomplete spinal cord injury, surgical interventions, and locomotor training.

Shah¹,

Song²,

Kim³

et al. 2011

Behavioral Neuroscience

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Estrous cycle disruption after spinal cord injury (SCI) in female rats is a common phenomenon. It remains unknown, however, if the aberrant estrous cycle is a result of an injury to the spinal cord itself or due to the general stress associated with surgical interventions. We addressed this issue by determining estrous cyclicality in female rats after a spinal cord hemisection (HX), implantation of EMG wires into selected hindlimb muscles, and/or injections of tracer dyes into the spinal cord. Since it is known that aerobic exercise can enhance the recovery of locomotor function in rodents with an incomplete SCI, we also determined if locomotor training positively impacts the disrupted estrous cycle after a HX. Estrous cycle assessments were made during a 5-8 week period in 27 female rats before and after HX, EMG, and/or dye injection surgeries and in HX rats that recovered spontaneously or underwent locomotor training. Our results show that estrous cyclicality was disrupted (cycle length >5 days) in approximately 76%, 46%, and 50% of the rats after HX, EMG, and dye injection surgeries, respectively. The cyclicality, however, was disrupted for a longer period after HX than after EMG or dye injection surgeries. Furthermore, estrous cycle mean length was shorter in the trained than non-trained HX group. These results suggest that estrous cycle disruption after a major SCI is a consequence of both the direct injury to the spinal cord and to the associated stress. Moreover, moderate aerobic exercise initiated early after a spinal cord HX returns the duration of the estrous cycle towards normal.

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CRF-receptor 1 blockade attenuates acute posttraumatic hyperglycemia in rats1

Cited by 6 publications

References 43 publications

An Experimental Model of Intestinal Resection and Compensated Non-Hypotensive Blood Loss

An Experimental Model of Intestinal Resection and Compensated Non-Hypotensive Blood Loss

Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients

Rodent estrous cycle response to incomplete spinal cord injury, surgical interventions, and locomotor training.

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