CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism

Klampfl, Stefanie M.; Brunton, Paula; Bayerl, Doris S.; Bosch, Oliver J.

doi:10.1016/j.psyneuen.2015.11.015

Cited by 27 publications

(44 citation statements)

References 58 publications

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“…Activation of CRF-R postpartum impairs the expression of maternal behavior thereby leading to maternal neglect (D'Anna and Gammie, 2009;Gammie et al, 2004;Klampfl et al, 2014Klampfl et al, , 2016Klampfl et al, 2013;Pedersen et al, 1991). Hence, hypoactivation of CRF-R during this sensitive period is an indispensable prerequisite for the appearance of appropriate maternal behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Maternal care was monitored on lactation day (LD) 1 before and after substance infusion (non-stress condition) as well as on LD 5 before and after substance infusion, which was combined with a psychosocial stressor (i.e. the maternal defense test; stress condition Bayerl et al, 2014;Klampfl et al, 2014Klampfl et al, , 2016Klampfl et al, 2013)). Observations were conducted for 10 s every 2 nd min in 30 min blocks according to an established protocol (Bosch and Neumann, 2008).…”

Section: Behavioral Testsmentioning

confidence: 99%

“…Given that the CRF-BP is up-regulated by acute stressor exposure (Herringa et al, 2004;McClennen et al, 1998;Stinnett et al, 2015), we suggest that its release in the BNST is induced by exposure to the maternal defense test. This up-regulation is certainly important to protect the dam from potentially elevated levels of CRF, which are detrimental for the appearance of maternal behavior (D'Anna and Gammie, 2009;Gammie et al, 2004;Klampfl et al, 2014Klampfl et al, , 2016Klampfl et al, 2013;Pedersen et al, 1991). However, it needs to be mentioned that, as yet, no reliable measure for CRF peptide release is available and, therefore, we can only speculate about the intra-BNST release of CRF during the maternal defense test.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Klampfl

Schramm

Stinnett

et al. 2016

Hormones and Behavior

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Section: Discussionmentioning

confidence: 99%

Section: Behavioral Testsmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Klampfl

Schramm

Stinnett

et al. 2016

Hormones and Behavior

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“…The test for anxiety‐related behaviour was performed using the elevated plus maze (EPM) as described earlier . Briefly, on LD 3, dams with their pups in their home cages were moved to the EPM testing room.…”

Section: Methodsmentioning

confidence: 99%

More than reproduction: Central gonadotropin‐releasing hormone antagonism decreases maternal aggression in lactating rats

Bayerl

Klampfl

Bosch

2019

J Neuroendocrinology

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Gonadotropin‐releasing hormone (GnRH) is a major regulator and activator of the hypothalamic‐pituitary‐gonadal axis. Many studies have demonstrated the importance of GnRH in reproduction and sexual behaviour. However, to date, only a single study shows an involvement of GnRH in maternal behaviour where a 30% reduction of GnRH neurones abolishes a mother's motivation to retrieve pups. On this basis, we aimed to investigate the effects of acute central GnRH receptor blockade in lactating rats on maternal care under non‐stress and stress conditions, maternal motivation in the pup retrieval test, maternal anxiety on the elevated plus maze, and maternal aggression in the maternal defence test. We found that acute central infusion of a GnRH antagonist ([d‐Phe2,6,Pro3]‐luteinising hormone‐releasing hormone; 0.5 ng 5 μL‐1) impaired a mother's attack behaviour against a female intruder rat during the maternal defence test compared to vehicle controls. However, in contrast to the previous study on reduced GnRH neurones, acute central GnRH antagonism did not affect pup retrieval, nor any other parameter of maternal behaviour or maternal anxiety. Taken together, GnRH receptor activation is mandatory for protection of the offspring. These findings shed new light on GnRH as a neuropeptide acting not exclusively on the reproductive axis but, additionally, on maternal behaviour including pup retrieval and maternal aggression.

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“…Importantly, the brain CRF system also modulates various social behaviors, like mother–infant interaction (Gammie et al 2004; Klampfl et al 2013, 2014, 2016) or pair bond formation in male prairie voles. In the latter, central activation of the CRF system facilitates pair bond formation, even in the absence of mating (DeVries et al 2002).…”

Section: Brain Mechanisms Underlying Pair Bond Formationmentioning

confidence: 99%

Oxytocin and Social Relationships: From Attachment to Bond Disruption

Bosch

Young

2017

Current Topics in Behavioral Neurosciences

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113

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Social relationships throughout life are vital for well-being and physical and mental health. A significant amount of research in animal models as well as in humans suggests that oxytocin (OT) plays an important role in the development of the capacity to form social bonds, the mediation of the positive aspects of early-life nurturing on adult bonding capacity, and the maintenance of social bonding. Here, we focus on the extensive research on a socially monogamous rodent model organism, the prairie vole (Microtus ochrogaster). OT facilitates mating-induced pair bonds in adults through interaction with the mesolimbic dopamine system. Variation in striatal OT receptor density predicts resilience and susceptibility to neonatal social neglect in female prairie voles. Finally, in adults, loss of a partner results in multiple disruptions in OT signaling, including decreased OT release in the striatum, which is caused by an activation of the brain corticotropin releasing factor (CRF) system. The dramatic behavioral consequence of partner loss is increased depressive-like behavior reminiscent of bereavement. Importantly, infusions of OT into the striatum of adults prevents the onset of depressive-like behavior following partner loss, and evoking endogenous OT release using melanocortin agonists during neonatal social isolation rescues impairments in social bonding in adulthood. This work has important translational implications relevant to the disruptions of social bonds in childhood and in adults.

show abstract

CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism

Cited by 27 publications

References 58 publications

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats

More than reproduction: Central gonadotropin‐releasing hormone antagonism decreases maternal aggression in lactating rats

Oxytocin and Social Relationships: From Attachment to Bond Disruption

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