Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?

Abstract

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Impact of COVID-19 Pandemic on Patients With Neurodegenerative Diseases

“…He died 2 months after onset. Examinations of EEG, MRI, CSF RT-QuIC, CSF 14-3-3, and tau protein highly indicated the diagnosis of sporadic CJD (sCJD) (Young et al, 2020). He displayed a fast progression and a short duration compared with majority of sCJD patients (Young et al, 2020).…”

“…Examinations of EEG, MRI, CSF RT-QuIC, CSF 14-3-3, and tau protein highly indicated the diagnosis of sporadic CJD (sCJD) (Young et al, 2020). He displayed a fast progression and a short duration compared with majority of sCJD patients (Young et al, 2020). It has been noticed that COVID-19 can sometimes trigger unspecific inflammatory in CNS (Ellul et al, 2020;Pan et al, 2020;Paterson et al, 2020).…”

Neurological issues during COVID-19: An overview

“…Patients with polyradiculoneuritis and cranial neuritis have also been described [ 25 ]. Rare cases of acute Parkinsonism and a single case of Creutzfeldt Jacob syndrome has been reported [ 26 ]. It remains unknown if other neurodegenerative diseases can be precipitated by this infection.…”

The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis

“…A recent case report of a > 60-year-old patient reported that the onset of clinical sCJD signs occurred concurrently with those of COVID-19 [ 250 ]. Further studies are clearly necessary to investigate this association, and coincidence cannot be entirely excluded.…”