2015
DOI: 10.1590/0100-3984.2014.0109
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Creutzfeldt-Jakob dementia

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“…Histopathological analysis is the gold standard diagnostic method, showing marked neuronal loss, spongiform changes, intense astrogliosis and immunoreactivity to the abnormal pathogenic isoform of the prion protein ( 11 ) . The prognosis is bleak, and death usually occurs within one year ( 2 , 9 ) .…”
mentioning
confidence: 99%
“…Histopathological analysis is the gold standard diagnostic method, showing marked neuronal loss, spongiform changes, intense astrogliosis and immunoreactivity to the abnormal pathogenic isoform of the prion protein ( 11 ) . The prognosis is bleak, and death usually occurs within one year ( 2 , 9 ) .…”
mentioning
confidence: 99%