Crenotherapy Modulates the Expression of Proinflammatory Cytokines and Immunoregulatory Peptides in Nasal Secretions of Children with Chronic Rhinosinusitis

Passariello, Annalisa; Costanzo, Margherita Di; Terrin, Gianluca; Iannotti, Antonio; Buono, Pietro; Balestrieri, U; Balestrieri, Gianni; Ascione, Enrico; Pedata, Monica; Canani, Francesco Berni; Canani, R. Berni

doi:10.2500/ajra.2012.26.3733

Cited by 23 publications

(29 citation statements)

References 32 publications

(37 reference statements)

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“…Many ENT disorders are widely treated by crenotherapy, including respiratory infections (13). Recurrent respiratory infections represent a relatively common problem in childhood.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, it was recently reported that crenotherapy with sulfate-sodium-chloride water modulated the expression of proinflammatory cytokines and immunoregulatory and antimicrobial peptides (such as TNF-a, human~-defensin 2, and calprotectin) in nasal secretions of children with chronic rhinosinusitis (13). In fact, a 15-day course of this thermal water inhalation by aerosol reduced these biomarkers as well as nasal symptoms and quality of life.…”

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confidence: 99%

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Salso-Sulphide Thermal Water in the Prevention of Recurrent Respiratory Infections in Children

Varricchio¹,

Giuliano²,

Capasso³

et al. 2013

Int J Immunopathol Pharmacol

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Recurrent respiratory infections (RRI) represent a social problem for both the pharmaco-economic impact and the burden on the family. Thermal water is popularly well accepted. However, there is no scientific evidence of its preventive activity on recurrent respiratory tract infections (RRI). Therefore, the purpose of this study was to evaluate the effects of Agnano thermal water nasal irrigation on RRI prevention in children. A total of 107 children (70 males, mean age 4.5±1.2 years) with RRI were enrolled in the study. At baseline, children were randomly assigned to the treatment with: A) inhaled crenotherapy with salso-sulphide water or B) isotonic saline (NaCl 0.9%). Inhaled therapy was performed using nasal washing by Rino-jet (ASEMA srl, Milan, Italy) b.i.d. for 12 days. Nasal washing lasted 2 minutes per nostril. Immediately before washing, children inhaled 1 l of water by stream inhalation per 2 minutes. Crenotherapy was capable of significantly reducing: the number of respiratory infections, nasal symptoms, neutrophil and bacteria count, turbinate and adenoidal hypertrophy, presence of biofilm, and blockage of ostiomeatal complex (OCM). In conclusion, this study provides the first evidence that Agnano crenotherapy may be capable of preventing RRI in children as it exerts some positive effects, such as reduction of nasal obstruction, OCM blockage, biofilm, and inflammatory events.

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“…Many ENT disorders are widely treated by crenotherapy, including respiratory infections (13). Recurrent respiratory infections represent a relatively common problem in childhood.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Salso-Sulphide Thermal Water in the Prevention of Recurrent Respiratory Infections in Children

Varricchio¹,

Giuliano²,

Capasso³

et al. 2013

Int J Immunopathol Pharmacol

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“…Apparently, crenotherapy acts as an antiinflammatory, a mucolytic, and a mucus and trophic regulator, thereby boosting the body's immune defenses (7)(8)(9)(10)(11). In particular, it induces vasodilatation and capillary permeability, stimulates the synthesis of IgAs, and reduces serum and tissue levels of IgE, thereby improving mucociliary clearance (7)(8)(9)(10)(11). Notwithstanding these results, the efficacy of crenotherapy in the treatment of CRS still remains unclear.…”

Section: Receivedaugust 302014 -Accepted October 21 2014mentioning

confidence: 99%

Nasal Cytological Assessment after Crenotherapy in the Treatment of Chronic Rhinosinusitis in the Elderly

Cantone

Ferranti

et al. 2014

Int J Immunopathol Pharmacol

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Chronic rhinosinusitis (CRS) determines irreversible alterations of the nasal mucosa with consequent impairment of ciliary movements and, therefore, mucociliary clearance (MCC). People of all ages can be affected by CRS but the elderly are subjects at the highest risk. CRS in the elderly with an age-related physiological impairment of nasal respiratory function, often accompanied by other chronic diseases, requires additional therapies to be added to the numerous daily medications. Since the currently available therapies for CRS include the use of drugs that can have adverse effects and contraindications, crenotherapy could represent a therapeutic option. Indeed, because the adverse effects and contraindications of crenotherapy are scarce, it can be safely used in elderly patients with comorbidities. The aim of this study is to evaluate the nasal cytological assessment after crenotherapy in elderly subjects with CRS. Two groups, comprising a total of 84 elderly subjects with CRS, were treated with crenotherapy with sodium chloride sulphate hyperthermal water rich in mineral salts (group I, n=49) and saline solution (group II n=35). Cytological assessment for both groups took place at baseline (T0) and 1 month after treatment (T30). At T30 the nasal cytological assessment showed statistically significant improvements in the ciliary motility and in the count of neutrophils and spores in group I, but not in group II. Conversely, there were no significant differences in the count of eosinophils, mast cells, bacteria and biofilm in either group. Our data for the first time focused on the role of crenotherapy in the improvement of cytological assessment of CRS in the elderly.

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“…The use of these waters for prophylactic and therapeutic purposes is called spa treatment and the curative effect stems from the heat of the water as well as its mineral content (Karagülle and Karagülle, 2000;Vaccarezza and Vitale, 2010). A recent study showed that in children with chronic rhinosinusitis a15 minute/15 day inhalation of thermal water containing sulfate, sodium and chloride results in the reduction nasal mucosal inflammatory mediators (Passariello et al, 2012). Yet other studies show that many mineral waters, especially those rich in bicarbonate, have an effect on lipoprotein levels and that their consumption causes a reduction in total serum cholesterol and LDL cholesterol levels (Schoppen et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Determination of Effects on Oxidant Antioxidant Balance and Some Biochemical Parameters Consumption of Bottled, Distilled and Deionized Thermal Water in Rats

Çevik¹,

Ulutaş²,

Demirel³

et al. 2016

Kocatepe Vet J

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The objective of this research is to determine the effects of the consumption of the bottled, distilled and deionized versions of thermal water taken from the Gazlıgöl district in the city of Afyonkarahisar on the oxidant -antioxidant balance and on certain biochemical parameters, along with possible effects on liver and kidney tissue. The research involved 6 rats in each group. The experiment group was given fresh, bottled, deionized and distilled thermal water for 30 days whereas the control group was given normal water. At the end of the experiment, rats' blood samples as well as liver, kidney and heart tissue samples were taken. The research determined that the hemoglobin level in rats that consumed bottled thermal water is considerably lower than those that consumed fresh and deionized water (p<0,05). The zinc level was meaningfully lower in rats that consumed distilled water than those in the other groups (p<0,05). There was no meaningful difference among the groups in terms of the liver and kidney tissues' MDA, GSH and SOD levels. Nevertheless, it was observed that the heart tissues' MDA level was higher in rats that consumed bottled and deionized water than those in other groups (p<0,01) whereas the GSH and SOD levels did not change. The histopathological examination of liver and kidney tissue showed certain pathological changes.The conclusion of the research is that thermal water does not have a positive effect on the organism.Key Words: Biochemical Parameters, Oxidant Antioxidant Balance, Thermal Water. Sıçanlarda Bekletilmiş, Distile ve Deiyonize Kaplıca Suyu Tüketilmesinin Oksidan Antioksidan Denge ve Bazı Biyokimyasal Parametreler Üzerine Etkisinin BelirlenmesiÖZ Bu çalışmada, Afyonkarahisar ilinin Gazlıgöl bölgesinden alınan kaplıca suyu ve bu suyun bekletilerek, distile ve deiyonize edilerek tüketilmesinin oksidan-antioksidan denge ve bazı biyokimyasal parametreler ile karaciğer ve böbrek dokusuna etkilerinin belirlenmesi amaçlanmıştır. Çalışmada her grupta 6 sıçan yer almıştır. 30 gün boyunca, deney grubundaki sıçanlara taze, bekletilmiş, deiyonize ve distile edilmiş kaplıca suyu, kontrol grubundakilere ise normal su verilmiştir. Deneme sonunda sıçanlardan kan numuneleri ile karaciğer, böbrek ve kalp doku örnekleri alınmıştır.Hemoglobin değeri bekletilmiş kaplıca suyu tüketen sıçanlarda taze ve deiyonize tüketen sıçanlara göre önemli oranda düşük olduğu gözlenmiştir(p<0,05). Distile edilmiş kaplıca suyu tüketen sıçanlarda Çinko değerinde diğer gruplara göre anlamlı (p<0,05) bir düşüş oluşmuştur. Karaciğer ve böbrek dokusu MDA, GSH ve SOD düzeyleri bakımından gruplar arasında anlamlı bir değişim gözlenmemiştir. Buna karşın, kalp dokusunda MDA düzeylerinin bekletilmiş ve deiyonize kaplıca suyu tüketen sıçanlarda diğer gruptakilere göre daha yüksek olduğu (p<0,01), GSH ile SOD düzeylerinin ise değişmediği saptanmıştır. Karaciğer ve böbrek dokusu hispatolojik incelemesinde birtakım patolojik değişiklikler tespit edilmiştir. Sonuç olarak çalışmada kullanılan kaplıca suyunun organizmada olumlu ...

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Crenotherapy Modulates the Expression of Proinflammatory Cytokines and Immunoregulatory Peptides in Nasal Secretions of Children with Chronic Rhinosinusitis

Abstract: Crenotherapy induced a down-regulation of nasal mucosal inflammatory mediators in children with CRS.

Cited by 23 publications

References 32 publications

Salso-Sulphide Thermal Water in the Prevention of Recurrent Respiratory Infections in Children

Salso-Sulphide Thermal Water in the Prevention of Recurrent Respiratory Infections in Children

Nasal Cytological Assessment after Crenotherapy in the Treatment of Chronic Rhinosinusitis in the Elderly

Determination of Effects on Oxidant Antioxidant Balance and Some Biochemical Parameters Consumption of Bottled, Distilled and Deionized Thermal Water in Rats

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