Ti6Al4Nb4Zr (mass%) was prepared by selective laser melting (SLM) under various conditions, and the microstructure evolution resulting from SLM processing and subsequent heat treatments was investigated. The effects of the unique SLM-induced microstructure on the high-temperature compressive strength and creep properties of the samples were then elucidated. Under rapid cooling conditions, the martensitic structure formed in a scale-like pattern, with a 100 µm in size, consistent with the laser scanning pattern. By contrast, under slow cooling conditions, the ¡/¢ lamellar structure formed in ¢ grains with a 300 µm grain size instead of in a scale-like pattern. The martensitic structure drastically changed to a Widmanstätten structure during heat treatment. The equiaxed ¡ phase also formed at the interface of the scale-like patterns. By contrast, the ¡/¢ lamellar structure did not exhibit a change in response to heat treatment. The compressive strength of the SLM samples was governed by the martensite ¡ size and the grain size, both of which depended on the cooling rate. The dominant creep deformation mechanism at 600°C and under a loading stress of 137 MPa was grain boundary sliding. The creep life depended on the grain size. The HIP treatment improved the creep life because it eliminated pores introduced by the SLM process.