The high temperature strength of the friction welded superalloy joint between cast polycrystalline Mar-M247 and the forged IN718 alloys has been investigated under low cycle and thermomechanical fatigue loadings, in comparison with those of the base materials. The experiments showed that the lives of the dissimilar joints were significantly influenced by the test conditions and loading modes. Not only the lives themselves but also the failure positions and mechanisms were sensitive to the loading mode. Especially under the loading conditions in which the creep-fatigue interaction was pronounced, some specific failure phenomena appeared in the DFW joint. The fracture behavior dependences on the loading modes and test conditions were discussed, based on analyses of the macroscopic elastic follow-up mechanism, the stress state by finite element method, and the inhomogeneous microstructure in the joint.