CREBRF is a potent tumor suppressor of glioblastoma by blocking hypoxia-induced autophagy via the CREB3/ATG5 pathway

Xue, Hao; Zhang, Jinsen; Guo, Xing; Wang, Jian; Li, Jiangbing; Gao, Xiao; Guo, Xiaofan; Li, Tong; Xu, Shugang; Zhang, Ping; Liu, Qinglin; Li, Gang

doi:10.3892/ijo.2016.3576

Cited by 49 publications

(41 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the function of CREBRF is minimally characterized, so the mechanisms by which rs373863828 affects these phenotypes are currently unclear. Individual studies have indicated that this transcription factor impacts glucocorticoid signaling, autophagy, unfolded protein response, and starvation resistance, as well as murine decidualization, embryo implantation, and maternal behavior (Audas, Li, Liang, & Lu, 2008; Li et al, 2016; Martyn et al, 2012; Minster et al, 2016; Xue et al, 2016; Yang et al, 2013). Future studies should aim to refine the effect of this variation on the related phenotypes of height, weight, and BMI in other Pacific Island populations, as well as other anthropometric traits.…”

Section: Discussionmentioning

confidence: 99%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2019

Preprint

View full text Add to dashboard Cite

ObjectivesStudies have demonstrated that rs373863828, a missense mutation in CREBRF, is associated with a number of anthropometric traits including body mass index (BMI), obesity, percent body fat, hip circumference, and abdominal circumference. Given the biological relationship between height and adiposity, we hypothesized that the effect of this variant on BMI might be due in part to a previously untested association of this variant with height.MethodsWe tested the hypothesis that minor allele of rs373863828 is associated with height in a Samoan population in two adult cohorts and in a separate cohort of children (age 5 - 18 years old) using linear mixed modeling.ResultsWe found evidence of a strong relationship between rs373863828 and greater mean height in Samoan adults (0.77 cm greater average height for each copy of the minor allele) with the same direction of effect in Samoan children.ConclusionsThese results suggest that the missense variant rs373863828 in CREBRF, first identified through an association with larger BMI, may be related to an underlying biological mechanism affecting overall body size including stature.

show abstract

Section: Discussionmentioning

confidence: 99%

A missense variant in CREBRF is associated with taller stature in Samoans

Carlson

Rosenthal

Russell

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…We found that 7 genes CREBRF, DIXDC1, AHNAK, CYBRD1, NOSTRIN, TNS2 and TNFSF12 were negatively correlated with the strongly interconnected cell cycle and mitosis clique. Indeed, a number of these genes have been identified as candidate tumor suppressor genes including CREBRF, DIXDC1, AHNAK and TNS2 [49–52]. Furthermore, NOSTRIN was found to be a potential negative regulator of disease aggressiveness in pancreatic cancer and CYBRD1 was identified as part of an iron regulatory gene signature that predicts outcome in BC [53, 54].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide screen identifies a novel prognostic signature for breast cancer survival

et al. 2017

View full text Add to dashboard Cite

Large genomic datasets in combination with clinical data can be used as an unbiased tool to identify genes important in patient survival and discover potential therapeutic targets. We used a genome-wide screen to identify 587 genes significantly and robustly deregulated across four independent breast cancer (BC) datasets compared to normal breast tissue. Gene expression of 381 genes was significantly associated with relapse-free survival (RFS) in BC patients. We used a gene co-expression network approach to visualize the genetic architecture in normal breast and BCs. In normal breast tissue, co-expression cliques were identified enriched for cell cycle, gene transcription, cell adhesion, cytoskeletal organization and metabolism. In contrast, in BC, only two major co-expression cliques were identified enriched for cell cycle-related processes or blood vessel development, cell adhesion and mammary gland development processes. Interestingly, gene expression levels of 7 genes were found to be negatively correlated with many cell cycle related genes, highlighting these genes as potential tumor suppressors and novel therapeutic targets. A forward-conditional Cox regression analysis was used to identify a 12-gene signature associated with RFS. A prognostic scoring system was created based on the 12-gene signature. This scoring system robustly predicted BC patient RFS in 60 sampling test sets and was further validated in TCGA and METABRIC BC data. Our integrated study identified a 12-gene prognostic signature that could guide adjuvant therapy for BC patients and includes novel potential molecular targets for therapy.

show abstract

“…First, topological analysis was conducted on the network, and the graph parameters indicated six lncRNAs and seven mRNAs as the hub nodes in the regulatory network. Among these genes, CAMTA1, CDC42 and RNF138 have been reported as oncogenes in multiple cancers, while CREBRF was a tumor suppressor in glioblastoma and a tumor promoter in gastric cancer . Furthermore, CAMTA1 and CDC42 could interact with several lncRNAs to make significant effects on the tumorigenesis …”

Section: Discussionmentioning

confidence: 99%

A novel lncRNA‐miRNA‐mRNA network analysis identified the hub lncRNA RP11‐159F24.1 in the pathogenesis of papillary thyroid cancer

et al. 2018

View full text Add to dashboard Cite

Papillary thyroid cancer (PTC) is one of the most common cancers worldwide, and its carcinogenesis is influenced by a complex network of gene interactions. In this study, the microarray expression profile was re‐annotated into a lncRNA‐mRNA biphasic profile. LncRNA‐mRNA interactions were confirmed by established miRNA‐RNA data and hypergeometric test. Then, a PTC‐related lncRNA‐miRNA‐mRNA network (PTCRN) was constructed by integrating differentially expressed genes with the RNA‐RNA networks. The new network consisted of 21 lncRNAs, 241 mRNAs and 803 edges. To prioritize PTC‐related genes, we performed topological analysis and random walk with restart (PWR) algorithm analysis of PTCRN. Both analyses identified lncRNA RP11‐159F24.1 as a hub node in the network, which could interact with 47 mRNAs by sponging miR‐485. In functional enrichment analysis, these interacting mRNAs were associated with the pathways in cancer. In validation, RP11‐159F24.1 (up‐regulated; P = 0.0013) showed an opposite expression pattern with its target miR‐485 (down‐regulated; P = 0.0013) in PTC, indicating that the RP11‐159F24.1/miR‐485/mRNAs axis might play an important role in the development of PTC. In conclusion, this study has constructed a PTC‐related lncRNA‐miRNA‐mRNA network and identified the hub lncRNA RP11‐159F24.1 in the tumorigenesis, which provided novel insights to explore the underlying mechanism of PTC.

show abstract

CREBRF is a potent tumor suppressor of glioblastoma by blocking hypoxia-induced autophagy via the CREB3/ATG5 pathway

Cited by 49 publications

References 47 publications

A missense variant in CREBRF is associated with taller stature in Samoans

A missense variant in CREBRF is associated with taller stature in Samoans

Genome-wide screen identifies a novel prognostic signature for breast cancer survival

A novel lncRNA‐miRNA‐mRNA network analysis identified the hub lncRNA RP11‐159F24.1 in the pathogenesis of papillary thyroid cancer

Contact Info

Product

Resources

About