Creativity in Parkinson's disease as a function of right versus left hemibody onset

Drago, Valeria; Foster, Paul S.; Skidmore, Frank; Heilman, Kenneth M.

doi:10.1016/j.jns.2008.09.026

Cited by 28 publications

(23 citation statements)

References 32 publications

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“…When examining the influence of the side of the body onset of PD, we did not find any association with creativity, on the contrary to previous work (50). …”

Section: Discussioncontrasting

confidence: 99%

Dopamine and the Biology of Creativity: Lessons from Parkinsonâ€™s Disease

Lhommée¹,

Batir

Quésada

et al. 2014

Front. Neurol.

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Background: Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization, and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems from a few case reports. We aim at demonstrating that creativity can be induced by dopaminergic treatments in PD, and tends to disappear after withdrawal of dopamine agonists.Methods: Eleven consecutive creative PD patients were selected from candidates for subthalamic nucleus deep brain stimulation (STN DBS) surgery, and compared to 22 non-creative control PD patients. Motor disability (UPDRS III), cognition (Frontal score, Mattis scale), and behavior (Ardouin scale) were assessed before surgery and 1 year after.Results: Before surgery, whereas cognitive and motor assessments were similar between groups, dopamine agonist (but not levodopa) dosages were higher in creative patients (p = 0.01). The Ardouin scale revealed also a specific psycho-behavioral profile of creative patients which had higher scores for mania (p < 0.001), hobbyism (p = 0.001), nocturnal hyperactivity (p = 0.041), appetitive functioning (p = 0.003), and ON euphoria (p = 0.007) and lower scores for apathy and OFF dysphoria (p = 0.04 for each). Post-operative motor, cognitive, and behavioral scores as dopaminergic treatment dosages were equivalent between groups. Motor improvement allowed for a 68.6% decrease in dopaminergic treatment. Only 1 of the 11 patients remained creative after surgery. Reduction of dopamine agonist was significantly correlated to the decrease in creativity in the whole population of study (Spearman correlation coefficient ρ = 0.47 with confidence index of 95% = 0.16; 0.70, p = 0.0053).Conclusion: Creativity in PD is linked to dopamine agonist therapy, and tends to disappear after STN DBS in parallel to reduction of dopamine agonists, which are relatively selective for the mesolimbic D3 dopamine receptors.

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“…When examining the influence of the side of the body onset of PD, we did not find any association with creativity, on the contrary to previous work (50). …”

Section: Discussioncontrasting

confidence: 99%

Dopamine and the Biology of Creativity: Lessons from Parkinsonâ€™s Disease

Lhommée¹,

Batir

Quésada

et al. 2014

Front. Neurol.

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“…Although these results do not agree with other studies which have demonstrated increased bilateral PFC activity during creative tasks (e.g., Folley & Park, 2005;HowardJones et al, 2005), it could be that this difference stems from the type of creativity examined, as these findings mostly come from verbal experimental designs. This is supported by lesion studies which have reported increased levels of figural creativity in patients with left brain lesions (Mendez, 2004), and suppressive deep brain stimulation of the left hemisphere in Parkinson's disease patients have also shown elevated artistic production (Drago, Foster, Skidmore, & Heilman, 2009). Therefore, in view of the importance of PFC in creative behaviour, it could be that functional enhancement of the right hemispheric frontal regions may result in figural creativity when coupled with a corresponding disengagement of the left PFC.…”

Section: Creativity and Schizotypymentioning

confidence: 73%

Neural correlates of creative thinking and schizotypy

2015

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“…The finding that semantic fluency predicted multi-tasking is not surprising considering that fluency measures reflect divergent thinking which has often been seen as a measure of creativity [47]. Divergent thinking appears to be crucial in multi-task situations specifically for the disengagement from current solutions and the development of alternative solutions [48]. Consequently, PD patients who show difficulties with divergent thinking are also very likely to suffer from problems in multi-tasking situations of everyday life.…”

Section: Discussionmentioning

confidence: 99%

Executive Functioning in Daily Life in Parkinson's Disease: Initiative, Planning and Multi-Task Performance

et al. 2011

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Impairments in executive functioning are frequently observed in Parkinson's disease (PD). However, executive functioning needed in daily life is difficult to measure. Considering this difficulty the Cognitive Effort Test (CET) was recently developed. In this multi-task test the goals are specified but participants are free in their approach. This study applies the CET in PD patients and investigates whether initiative, planning and multi-tasking are associated with aspects of executive functions and psychomotor speed. Thirty-six PD patients with a mild to moderate disease severity and thirty-four healthy participants were included in this study. PD patients planned and demonstrated more sequential task execution, which was associated with a decreased psychomotor speed. Furthermore, patients with a moderate PD planned to execute fewer tasks at the same time than patients with a mild PD. No differences were found between these groups for multi-tasking. In conclusion, PD patients planned and executed the tasks of the CET sequentially rather than in parallel presumably reflecting a compensation strategy for a decreased psychomotor speed. Furthermore, patients with moderate PD appeared to take their impairments into consideration when planning how to engage the tasks of the test. This compensation could not be detected in patients with mild PD.

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Creativity in Parkinson's disease as a function of right versus left hemibody onset

Cited by 28 publications

References 32 publications

Dopamine and the Biology of Creativity: Lessons from Parkinsonâ€™s Disease

Dopamine and the Biology of Creativity: Lessons from Parkinsonâ€™s Disease

Neural correlates of creative thinking and schizotypy

Executive Functioning in Daily Life in Parkinson's Disease: Initiative, Planning and Multi-Task Performance

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