Creation, Physical and Chemical Properties of Alkil-2-((5-Phenethyl-4-R-1,2,4- Triazole-3-Yl)thio)acet(propan,benz)imidates

Abstract

Objective: The aim of this research was to synthesize and evaluate physical-chemical properties of 5-pheneyhyl-4-R-3-thio-1,2,4-triazole and to establish identity and structure of the synthesized compounds, namely alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)acet(propan,benz)imidates.
 Methods: As starting materials for synthesis of alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)acet(propan,benz)imidates, the corresponding 2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)aceto(propane,benzo)nitrile have been used. Synthesis has been set in the absolute alcohol medium (propanol or butanol alcohol) with chloroform, using the saturation with dry hydrogen chloride.
 Results: In this study, we have developed nine new compounds have been received as a result of synthetic transformations, the structure of synthesized compounds has been confirmed by modern complex of physical-chemical methods of analysis (1H NMR-spectroscopy, elemental analysis), and their individuality has been conducted on gas-liquid chromatograph Agilent 1260 Infinity HPLC equipped with a mass spectrometer Agilent 6120.
 Conclusion: As a result of the work, it was synthesized the new compounds of the series of alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio) acet(propan,benz)imidates and was characterized by elemental analysis and proton nuclear magnetic resonance spectroscopic analysis.

The synthesis of 3-methyl-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives

“…As a result of this study 10 new substances of the 3-methyl-6-R- [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazole series have been obtained. The structure and purity of the products have been confirmed using 1 Н NMR spectroscopy, LC-MS and elemental analysis.…”

“…. For example, obtaining 6-(2-fluorophenyl)-3-methyl-[1,2,4]triazolo-[3,4-b][1,3,4]thiadiazole 3a was confirmed by the signals of the corresponding 2-fluorophenyl and methyl groups attached to the 1,2,4-triazole nucleus. The 1 H NMR spectrum for compound 3a was characterized by a chemical shift in a strong field appearing as a triple proton singlet of the methyl group bound with 1,2,4-triazole ring at 2.54 ppm.…”

“…Development of new synthetic approaches for obtaining 1,2,4-triazole derivatives that may be used in medical and biological studies is of great significance for synthetic chemists [13,14]. Therefore, the aim of this work was to synthesize and confirm the structure of new potentially biologically active derivatives of the 3-methyl-6-R- [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazole series.…”

“…To attain the aim 4-amino-5-methyl-4H-1,2,4triazole-3-thiol 1 was used as an initial compound [17]. Heterocyclization of compound 1 with carboxylic acids 2a -j was carried out in the excess of phosphorus oxychloride, yielding 3-methyl-6-R- [1,2,4] The LC-MS analysis revealed individual peaks of the compounds synthesized on chromatograms, while the mass-to-charge ratios corresponded to the molecular masses of the compounds ( Table 2).…”

“…H NMR spectra and LC-MS data for 3-methyl-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 3a -j 3H, s, CH 3 ), 2.14 (3H, dddd, J 1 = 13.6 Hz, J 2 = 6.8 Hz, J 3 = 6.3 Hz, J 4 = 0.7 Hz, adamantan-1-yl), 2.06 (6H, dd, J 1 = 6.8 Hz, J 2 = 0.8 Hz, adamantan-1-yl), 1.83 -1.72 (6H, m, adamantan-1-yl) 275.38…”