Creation of Hierarchical Microchannel Architecture within Tissue-Engineered Hydrogels using Melt-Spun Sacrificial Fibers

Improved cellular infiltration into 3D interconnected microchannel scaffolds formed by using melt-spun sacrificial microfibers

“…3,4 Manufacturing techniques such as solvent casting-particulate leaching, 5 gas foaming, 6 phase separation, 7 bre meshes, 8 rapid prototyping 9 and excimer laser photocuring 10,11 have been used to generate porous scaffolds. To produce scaffolds with desired 3D microarchitecture, sacricial porogens such as 3D printed polyvinyl alcohol (PVA) 12 and melt-spun shellac micro-bers 13,14 were used to fabricate 3D interconnected gelatin hydrogel or polydimethylsiloxane (PDMS) scaffold.…”