Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance

Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz

“…The most widely used modeling method was potassium oxazinate to specifically inhibit urate oxidase activity to inhibit uric acid decomposition. 32 Using this method, we found that the SUA level in the HUA group was significantly increased, indicating that the modeling was successful. Meanwhile, our results showed that ASTE and FASTE could decrease the contents of SUA, SCR and BUN, as well as the activity of XOD and ADA in the serum and liver.…”

Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels

“…In addition, NO (also known as an endothelial-derived relaxing factor, EDRF), as an important mediator regulating vascular tone, is also affected by the decrease of renal blood flow that caused the impairment of vasodilation function [58,59] . Therefore, the level of NO is another biomarker for hyperuricemia [60] . Figure 3d shows the NO levels in all groups at different intervals.…”

“…59,60 Therefore, the level of NO is another biomarker for hyperuricemia. 61 Fig. 3d shows the NO levels among all groups at different intervals.…”

Design, Synthesis and Biological Activity of Low‐Molecular‐Weight URAT1 Inhibitors**

“…Among all of these compounds, compound 1 revealed the best inhibition activity on URAT1 in vitro. We established a stable acute hyperuricemia mouse model [18,19] to evaluate the in vivo efficacy of the newly synthesized compounds in reducing SUA concentration. As shown in Figure 3, the SUA levels were decreased in tested compounds (except for compound 3) compared to model group.…”