Creation of a Tumor-Mimic Model Using a Muscle Paste for Radiofrequency Ablation of the Lung

Kawai, Takeshi; Kaminou, Toshio; Sugiura, Kimihiko; Hashimoto, Masayuki; Ohuchi, Yasufumi; Adachi, Akira; Fujioka, Shozo; Ito, Hisao; Nakamura, Kenji; Ogawa, Toshihide

doi:10.1007/s00270-008-9463-9

Cited by 14 publications

(9 citation statements)

References 10 publications

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“…Due to the lack of lung tumor properties in literature, the tumor tissue was approximated by muscle as previously suggested 39 . Specific baseline values at physiologic temperature were again taken from the IT’IS database and temperature dependencies of thermal properties from the literature, as noted in the fourth column of Table II.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the lack of lung tumor properties in literature, the tumor tissue was approximated by muscle as previously suggested. 39 Specific baseline values at physiologic temperature were again taken from the IT'IS database and temperature dependencies of thermal properties from the literature, as noted in the fourth column of Table II. Dielectric properties of tumors were approximated in few different ways to study the impact of contrast between tumor and background tissue to resulting ablation and treatment plan, as described in the following subsection.…”

Section: D Tissue Properties and Their Variabilitymentioning

confidence: 99%

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Microwave ablation of lung tumors: A probabilistic approach for simulation‐based treatment planning

Šebek

Taeprasartsit

Wibowo³

et al. 2021

Medical Physics

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Purpose: Microwave ablation (MWA) is a clinically established modality for treatment of lung tumors. A challenge with existing application of MWA, however, is local tumor progression, potentially due to failure to establish an adequate treatment margin. This study presents a robust simulation-based treatment planning methodology to assist operators in comparatively assessing thermal profiles and likelihood of achieving a specified minimum margin as a function of candidate applied energy parameters. Methods: We employed a biophysical simulation-based probabilistic treatment planning methodology to evaluate the likelihood of achieving a specified minimum margin for candidate treatment parameters (i.e., applied power and ablation duration for a given applicator position within a tumor). A set of simulations with varying tissue properties was evaluated for each considered combination of power and ablation duration, and for four different scenarios of contrast in tissue biophysical properties between tumor and normal lung. A treatment planning graph was then assembled, where distributions of achieved minimum ablation zone margins and collateral damage volumes can be assessed for candidate applied power and treatment duration combinations. For each chosen power and time combination, the operator can also visualize the histogram of ablation zone boundaries overlaid on the tumor and target volumes. We assembled treatment planning graphs for generic 1, 2, and 2.5 cm diameter spherically shaped tumors and also illustrated the impact of tissue heterogeneity on delivered treatment plans and resulting ablation histograms. Finally, we illustrated the treatment planning methodology on two example patient-specific cases of tumors with irregular shapes. Results: The assembled treatment planning graphs indicate that 30 W, 6 min ablations achieve a 5mm minimum margin across all simulated cases for 1-cm diameter spherical tumors, and 70 W, 10 min ablations achieve a 3-mm minimum margin across 90% of simulations for a 2.5-cm diameter spherical tumor. Different scenarios of tissue heterogeneity between tumor and lung tissue revealed 2 min overall difference in ablation duration, in order to reliably achieve a 4-mm minimum margin or larger each time for 2-cm diameter spherical tumor. Conclusions: An approach for simulation-based treatment planning for microwave ablation of lung tumors is illustrated to account for the impact of specific geometry of the treatment site, tissue property uncertainty, and heterogeneity between the tumor and normal lung.

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Section: Methodsmentioning

confidence: 99%

Section: D Tissue Properties and Their Variabilitymentioning

confidence: 99%

Microwave ablation of lung tumors: A probabilistic approach for simulation‐based treatment planning

Šebek

Taeprasartsit

Wibowo³

et al. 2021

Medical Physics

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“…A tumor-mimic model, as developed by Kawai et al [19] to simulate RFA of tumor tissue, was used to create a lytic lesion in the posterior part of the vertebral body. For this purpose, a transpedicular access was established with a 9 G biopsy needle.…”

Section: Methodsmentioning

confidence: 99%

Thermometry during coblation and radiofrequency ablation of vertebral metastases: a cadaver study

Groetz

Birnbaum²,

Meyer

et al. 2013

Eur Spine J

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Purpose To evaluate safety of coblation of simulated lytic metastases in human cadaveric vertebral bodies by measuring heat distribution during thermal tissue ablation and comparing it to radiofrequency ablation (RFA). Materials and methods Three devices were compared: a 10 mm single-needle RFA electrode, a 20 mm array RFA electrode and the coblation device. To simulate bone metastases, a spinal tumor model was used stuffing a created lytic cavity with muscle tissue. Measuring of heat distribution was performed during thermal therapy within the vertebral body, in the epidural space and at the ipsilateral neural foramen. Eight vertebral bodies were used for each device. Results Temperatures at heat-sensitive neural structures during coblation were significantly lower than using RFA. Maximum temperatures measured at the end of the procedure at the neural foramen: 46.4°C (±2.51; RFA 10 mm), 52.2°C (±5.62; RFA 20 mm) and 42.5°C (±2.88; coblation). Maximum temperatures in the epidural space: 46.8°C (±4.7; RFA 10 mm), 49.5°C (±6.48; RFA 20 mm) and 42.1°C (±2.5; coblation). Maximum temperatures measured within the vertebral body: 50.6°C (±10.48; RFA 10 mm), 61.9°C (±15.39; RFA 20 mm) and 54. 4°C (±15.77; coblation). Conclusion In addition to RFA, the application of coblation is a safe method to ablate vertebral lesions with regards to heat distribution at heat-sensitive neural spots. The measured temperatures did not harbor danger of thermal damage to the spinal cord or the spinal nerves.

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“…To create artificial lesions those have similar characteristics to real tumor tissue echogenicity and have similar ablation attributes, agarose [5][6][7][8][9] or fluid, composed of purified bovine serum albumin and glutaraldehyde [10] were used in various organs. Others used gelatin [8,9,11] chromatic alginate [11], ultrasound gel [12], paste made of animal muscle tissue [13][14][15] or liquid plastics [16]. Viable tumor cells were transplanted into living animals [17,18] for testing models and real lesion morphology was imitated with implanted lesions made from polymer [19,20].…”

Section: Introductionmentioning

confidence: 99%

Human Cadaveric Artificial Lung Tumor-Mimic Training Model

Székely

Suhai

Karlinger

et al. 2021

Pathol. Oncol. Res.

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Introduction: An important phase in surgical training is gaining experience in real human anatomical situations. When a cadaver is available it may complement the various artificial practice models. However, it is often necessary to supplement the characteristics of the cadavers with a simulation of a tumor. Our objective was to develop an easy-to-create, realistic artificial tumor-mimic model for peripheral lung tumor resection practice.Methods: In our work we injected barium sulphate enriched silicone suspension into 10 isolated, non-fixed lungs of human cadavers, through the puncture of the visceral pleura. Four lesions–apical, hilar and two peripheral–were created in each of ten specimens. After fixation CT scans were obtained and analyzed. The implanted tumor-mimics were examined after anatomical preparation and slicing. Also performed CT-guided percutaneous puncture was also performed to create the lesions in situ in two lungs of human cadavers.Results: Analyzing the CT data of 10 isolated lungs, out of 40 lesions, 34 were nodular (85.0%) and in the nodular group five were spiculated (12.5%). Satellite lesions were formed in two cases (5.0%). Relevant outflow into vessels or airway occurred in five lesions (12.5%). Reaching the surface of the lung occured in 11 lesions (27.5%). The tumor-mimics were elastic and adhered well to the surrounding tissue. The two lesions, implanted via percutaneous puncture, both were nodular and one also showed lobulated features.Conclusion: Our artificial tumor-mimics were easy to create, varied in shape and size, and with percutaneous implantation the lesions provide a model for teaching every step of a surgical procedure.

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Creation of a Tumor-Mimic Model Using a Muscle Paste for Radiofrequency Ablation of the Lung

Cited by 14 publications

References 10 publications

Microwave ablation of lung tumors: A probabilistic approach for simulation‐based treatment planning

Microwave ablation of lung tumors: A probabilistic approach for simulation‐based treatment planning

Thermometry during coblation and radiofrequency ablation of vertebral metastases: a cadaver study

Human Cadaveric Artificial Lung Tumor-Mimic Training Model

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