Creation of a refractive lens within an existing intraocular lens using a femtosecond laser

Sahler, Ruth; Bille, Josef F.; Enright, Sean; Chhoeung, Somaly; Chan, Kevin

doi:10.1016/j.jcrs.2016.05.005

Cited by 28 publications

(13 citation statements)

References 5 publications

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“…It appears to induce chemical changes in the IOL substrate which affect its refractive index, without affecting the overall modulation transfer function of the IOL and is biocompatible in a rabbit model. [106][107][108] This application of FL technology has yet to be performed in vivo on a human but may allow refining the post-operative refraction including toricity or multifocality.…”

Section: Future Applications Of Flacs Under Current Investigationmentioning

confidence: 99%

Femtosecond laser–assisted cataract surgery: A review

Roberts,

Day,

O’Brart

2019

European Journal of Ophthalmology

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Purpose: Review scientific literature concerning femtosecond laser–assisted cataract surgery. Methods: Following databases were searched: CENTRAL (Cochrane Eyes and Vision Trials Register; Cochrane Library: Issue 2 of 12, June 2019), Ovid MEDLINE® without Revisions (1996 to June 2019), Ovid MEDLINE® (1946 to June 2019), Ovid MEDLINE® Daily Update June 2019, MEDLINE and MEDLINE Non-Indexed Items, Embase (1980–2019), Embase (1974 to June 2019), Ovid MEDLINE® and Epub Ahead of Print, in-Process & Other Non-Indexed Citations and Daily (1946 to June 2019), Web of Science (all years), the metaRegister of Controlled Trials ( www.controlled-trials.com ), ClinicalTrials.gov ( www.clinicaltrial.gov ) and World Health Organization International Clinical Trials Registry Platform ( www.who.int/ictrp/search/en ). Search terms/keywords included ‘Femtosecond laser’ combined with ‘cataract’, ‘cataract surgery’. Results: Based on quality of their methodology and their originality, 121 articles were reviewed, including randomised controlled trials, cohort studies, case-controlled studies, case series, case reports and laboratory studies. Each step of the femtosecond laser–assisted cataract surgery procedure (corneal incisions, arcuate keratotomies, capsulotomy and lens fragmentation) has been discussed with relevance to published outcomes, as well as complication rates of femtosecond laser–assisted cataract surgery, and what we can learn from the larger studies/meta-analyses and the economics of femtosecond laser–assisted cataract surgery within different healthcare settings. Conclusion: Studies suggest that the current clinical outcomes of femtosecond laser–assisted cataract surgery are not different to conventional phacoemulsification surgery and it is not cost effective when compared with conventional phacoemulsification surgery. In its current technological form, it is a useful surgical tool in specific complex cataract scenarios, but its usage has not been shown to translate into better clinical outcomes.

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Section: Future Applications Of Flacs Under Current Investigationmentioning

confidence: 99%

Femtosecond laser–assisted cataract surgery: A review

Roberts,

Day,

O’Brart

2019

European Journal of Ophthalmology

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“…1 MHz speed. The physical parameters of the procedure, like scan-speed, wavelength, pulse rate, energy per pulse, etc., are provided in [7], as well as data on the homogeneity of refractive index change. In preparation of a RIS lens, the femtosecond laser is directed to a small area within the polymeric IOL.…”

Section: Femtosecond Laser Induced Refractive Index Change (Ris)mentioning

confidence: 99%

Chemical basis for alteration of an intraocular lens using a femtosecond laser

Bille¹,

Engelhardt²,

Volpp³

et al. 2017

Biomed. Opt. Express

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Abstract:The chemical basis for the alteration of the refractive properties of an intraocular lens with a femtosecond laser was investigated. Three different microscope setups have been used for the study: Laser Induced Fluorescence (LIF) microscopy, Raman microscopy and coherent anti-Stokes Raman Scattering (CARS) microscopy. Photo-induced hydrolysis of polymeric material in aqueous media produces two hydrophilic functional groups: acid group and alcohol group. The spectral signatures identify two of the hydrophilic polar molecules as N-phenyl-4-(phenylazo)-benzenamine (C 18 H 15 N 3 ) and phenazine-1-carboxylic acid (C 13 H 8 N 2 O 2 ). The change in hydrophilicity results in a negative refractive index change in the laser-treated areas.

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“…The consistency and precision of the power changes induced by the laser have been shown in vitro. Another recent study [13] found that the refractive-index change altered the dioptric power of commercially available yellow hydrophobic acrylic IOLs to within ±0.1 D of the targeted change without a significant reduction in the MTF. A more recent study performed in our laboratory also showed the consistency and precision of the power change by this technology in commercially available hydrophobic acrylic lenses with and without a blue-light filter, without inducing significant changes in IOL light transmission.…”

Section: Biocompatibility Of Intraocular Lens Power Adjustmentmentioning

confidence: 96%

“…1 MHz speed. The physical parameters of the procedure, like scan speed, wavelength, pulse rate, energy per pulse, etc., are provided in [13], as well as data on the homogeneity of refractive index change. In preparation of a RIS lens, the femtosecond laser is directed to a small area within the polymeric IOL.…”

Section: Femtosecond Laser-induced Refractive Index Change (Ris)mentioning

confidence: 99%