Creation of a Composite Bioactive Coating with Antibacterial Effect Promising for Bone Implantation

Abstract

When creating titanium-containing bone implants, the bioactive coatings that promote their rapid engraftment are important. The engraftment rate of titanium implants with bone tissue depends significantly on the modification of the implant surface. It is achieved by changing either the relief or the chemical composition of the surface layer, as well as a combination of these two factors. In this work, we studied the creation of composite coatings with a two-level (the micro- and nanolevel) hierarchy of the surface relief, which have bioactive and bactericidal properties, which are promising for bone implantation. Using the developed non-lithographic template electrochemical synthesis, a composite coating on titanium with a controlled surface structure was created based on an island-type TiO2 film, silver and hydroxyapatite (HAp). This TiO2/Ag/HAp composite coating has a developed surface relief at the micro- and nanolevels and has a significant cytological response and the ability to accelerate osteosynthesis, and also has an antibacterial effect. Thus, the developed biomaterial is suitable for production of dental and orthopedic implants with improved biomedical properties.

Structure and mechanical properties of a composite based on titanium and a bioactive coating with a two-level surface relief

“…Figure 1 shows micrographs of the synthesized TiO 2 oxide coating (template), the morphology of which is characterized by the presence of micro-and nano-roughnesses. Two-level relief hierarchy significantly increases the bioactivity of the implant surface [15].…”

“…The resulting coatings have a developed surface relief consisting of micro-and nano-irregularities, and due to this the bioactivity of the implant increases, since it contributes to the accelerated osteoblast differentiation [15].…”

“…In this work, we investigated the structure and mechanical properties of a Ti-based composite with TiO 2 /Ag/HAp coating with a controlled composition and surface relief at the microand nanoscale. The coating was developed by us [15] using a combined sol-gel synthesis and electrochemical deposition from solution and showed high bioactive properties. The mechanical characteristics of the coating and the coated implant also affect the rate of bone tissue engraftment to the implant surface.…”