Creation, evolution, and future challenges of ion beam therapy from a medical physicist’s viewpoint (part 1). Introduction and Chapter 1. accelerator and beam delivery system

Endo, Masahiro

doi:10.1007/s12194-022-00681-3

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…In this case, many irradiated cells disable their capacity to repair the lesions after higher LET radiation, where the RBE can increase. Their advantageous biological effects have in the meantime been realized in several thousand successfully treated patients, while minor patients with breast cancer ( 19 ). However, in clinical operation, RBE depends on several factors, such as cell lines, radiation dose, fractionation, cell cycle, and oxygenation.…”

Section: Introductionmentioning

confidence: 99%

Particle radiotherapy for breast cancer

Ruan,

Okamoto,

Ohno

et al. 2023

Front. Oncol.

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Breast cancer is the most common malignant tumor in female patients. Along with surgery, radiotherapy is one of the most commonly prescribed treatments for breast cancer. Over the past few decades, breast cancer radiotherapy technology has significantly improved. Nevertheless, related posttherapy complications should not be overlooked. Common complications include dose-related coronary toxicity, radiation pneumonia, and the risk of second primary cancer of the contralateral breast. Particle radiotherapy with protons or carbon ions is widely attracting interest as a potential competitor to conventional photon radiotherapy because of its superior physical and biological characteristics. This article summarizes the results of clinical research on proton and carbon-ion radiotherapy for treating breast cancer

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Section: Introductionmentioning

confidence: 99%

Particle radiotherapy for breast cancer

Ruan,

Okamoto,

Ohno

et al. 2023

Front. Oncol.

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“… 14 , 15 ) Particle beams such as proton and carbon ion beams, which are physically more suitable than photons beams such as X-rays and gamma-rays to focus ionization to the tumor, have emerged as new EBRT modalities. 16 , 17 ) With the progress in the treatment planning and therapeutic machinery, highly precise positioning of tumors in spatial-temporal co-ordinates became a dominating issue. 16 , 18 – 20 ) However, it has not been established whether we could increase cure rates without increases in radiation-induced adverse effects in cancer patients with the improvement in physical accuracy.…”

Section: Introductionmentioning

confidence: 99%

Biomedical advances and future prospects of high-precision three-dimensional radiotherapy and four-dimensional radiotherapy

SHIRATO

2023

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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Biomedical advances of external-beam radiotherapy (EBRT) with improvements in physical accuracy are reviewed. High-precision (±1 mm) three-dimensional radiotherapy (3DRT) can utilize respective therapeutic open doors in the tumor control probability curve and in the normal tissue complication probability curve instead of the one single therapeutic window in two-dimensional EBRT. High-precision 3DRT achieved higher tumor control and probable survival rates for patients with small peripheral lung and liver cancers. Four-dimensional radiotherapy (4DRT), which can reduce uncertainties in 3DRT due to organ motion by real-time (every 0.1–1 s) tumor-tracking and immediate (0.1–1 s) irradiation, have achieved reduced adverse effects for prostate and pancreatic tumors near the digestive tract and with similar or better tumor control. Particle beam therapy improved tumor control and probable survival for patients with large liver tumors. The clinical outcomes of locally advanced or multiple tumors located near serial-type organs can theoretically be improved further by integrating the 4DRT concept with particle beams.

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Creation, evolution, and future challenges of ion beam therapy from a medical physicist’s viewpoint (Part 2). Chapter 2. Biophysical model, treatment planning system and image guided radiotherapy

Endo

2023

Radiol Phys Technol

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Creation, evolution, and future challenges of ion beam therapy from a medical physicist’s viewpoint (part 1). Introduction and Chapter 1. accelerator and beam delivery system

Cited by 4 publications

References 32 publications

Particle radiotherapy for breast cancer

Particle radiotherapy for breast cancer

Biomedical advances and future prospects of high-precision three-dimensional radiotherapy and four-dimensional radiotherapy

Creation, evolution, and future challenges of ion beam therapy from a medical physicist’s viewpoint (Part 2). Chapter 2. Biophysical model, treatment planning system and image guided radiotherapy

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