Creatinine reabsorption by the aged kidney

Musso, Carlos G.; Michelángelo, Hernán; Vilas, Manuel; Reynaldi, Juliana; Martínez, B.; Algranati, L; Núñez, Juan F. Macías

doi:10.1007/s11255-008-9508-7

Cited by 57 publications

(48 citation statements)

References 14 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ROS causes the elevation of the free radical level within the body. Free radicals could damage the structure and function of various tissues, including renal tissue [4]. Histopathological damage on the structure and function of renal tissue has been previously reported as glomeruli hypertrophy, glomeruschlerosis, and swelling, apoptosis, and the necrosis of renal proximal tubular epithelial cells [5].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Husen¹,

Khaleyla²,

Ansori³

et al. 2018

Proceedings of the 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change A

View full text Add to dashboard Cite

Abstract-This research was aimed to investigate the ability of a alpha-mangostin compound derived from mangosteen pericarp to reduce plasma blood urea nitrogen (BUN) and creatinine level, and also to ameliorate the damaged renal proximal tubular of the kidneys in diabetic mice. An in-vivo antioxidant test was conducted using male BALB/c mice. The mice were divided into two groups; normal control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-doses of 30 mg/kg injected for five consecutive days. The diabetic mice were separated again into three sub-groups; diabetic control (KD), diabetic mice treated with Metformin HCl (KM), and diabetic mice treated with alpha-mangostin. The alpha-mangostin treatment group was categorised based on the dose given; P1 (2 mg/kg body weight), P2 (4 mg/kg body weight) and P3 (8 mg/kg body weight). Before and after STZ injection, the body weight and fasting blood glucose were measured. The body weight and fasting blood glucose were measured on the 1 st , 7 th , and 14 th day of alpha-mangostin treatment. Alpha-mangostin was given orally for 14 days. On the 15 th day, the plasma BUN and creatinine level were measured using Pentra C 200. Interestingly, the administration of alpha-mangostin was able to lower the plasma BUN and creatinine level, and also the ameliorate-damaged renal proximal tubular epithelial cells of the kidney in diabetic mice leseened significantly.

show abstract

Section: Resultsmentioning

confidence: 99%

“…ROS within the body will elevate free radicals. Free radicals are able to damage various tissues in the body, including renal proximal tubular tissue [4].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Husen¹,

Khaleyla²,

Ansori³

et al. 2018

Proceedings of the 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change A

View full text Add to dashboard Cite

show abstract

“…Studies of intestinal dialysis have shown a daily flow of 71 grams of urea, 2.9 grams of creatinine, 2.5 grams of uric acid and 2.0 grams of phosphate into the intestinal fluid (16). Accordingly, various invasive and noninvasive attempts including external gut fistula, intestinal dialysis, induced diarrhea, and administration of oral sorbents and/or encapsulated urease enzyme have been made to extract uremic waste from the gastrointestinal tract (2,3,(7)(8)(9)(10)(11)(12)(13)(14)(15). The second part of our protocol was the use of prebiotic.…”

Section: Discussionmentioning

confidence: 99%

“…At present, AST-120 is widely used as an approved drug in Japan for the treatment of approximately 20,000 undialysed uremic patients to delay the progression of CRF. However, AST-120 is not yet available outside Japan (11)(12). The aim of our proposed dialysis free protocol is to introduce another type of renal replacement therapy for selective patients with advanced CKD.…”

mentioning

confidence: 99%

Dialysis Free Protocol for Some End Stage Renal Disease Patients (Khosroshahi Protocol)

Khosroshahi

Kalantar‐Zadeh

2012

FFHD

View full text Add to dashboard Cite

ABSTRACT:Background: The number of patients with End Stage Renal Disease (ESRD) is growing annually around the world. Provision of renal replacement therapy in the form of dialysis and transplant is relatively expensive. Recent studies have shown no survival benefit of early initiation of dialysis. Given recent outcome data of the timing of dialysis treatment and the expenses and logistics of hemodialysis procedure have stimulated research on alternative strategies. The aim of this study is to introduce another type of renal replacement therapy for selective patients with advanced chronic kidney disease (CKD). Methods:In a case series we used a so-called "dialysis free protocol" consisting of a low protein diet, uremic toxin adsorbents, and prebiotics for selective ESRD patients who had dialysis access constraints or did not agree placement of hemodialysis vascular access or peritoneal dialysis catheter.Findings: clinical and biochemical results of this study showed that these patients were not deteriorating during the study period and Blood Urea Nitrogen (Bun) & serum creatinin levels were not elevated in these months. Participating patients were relatively well throughout the study without signs of florid uremia and without a need for emergent or urgent dialysis. Conclusion:We conclude that our proposed dialysis free protocol reduces the need for dialysis treatment at least transiently. Whether this protocol can reduce the need for dialysis treatment requires additional studies.

show abstract

“…More recently other solutes, including urea, uric acid, and lithium, have been investigated with the goal of improvement in the diagnostic ability to distinguish between PRA and ATN. [44][45][46][47][48][49][50][51][52][53][54] In an effort to evaluate these studies and the particular problems with each solute, we will briefly review the physiology of their renal handling in water deprivation states.…”

Section: Introductionmentioning

confidence: 99%

Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia

et al. 2010

View full text Add to dashboard Cite

While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ability to distinguish pre-renal azotemia from acute tubular necrosis. Nevertheless, there are many drugs and medical conditions that interfere with that utility and recently other solutes, including urea, uric acid and lithium, have been recently investigated to improve the diagnostic ability in clinical situations where the fractional excretion of sodium is known to be unreliable. We review the tubular physiology of these solutes and show how the differences in tubular physiology might be exploited to develop a strategy for their optimal clinical use.

show abstract

Creatinine reabsorption by the aged kidney

Abstract: Our findings indicate that there seems to be a net reabsorption of creatinine in the renal tubules of healthy old persons.

Cited by 57 publications

References 14 publications

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

Dialysis Free Protocol for Some End Stage Renal Disease Patients (Khosroshahi Protocol)

Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia

Contact Info

Product

Resources

About