Abstract:4536
Background
Allogeneic hematopoietic cell transplantation (HCT) is the only proven cure for pediatric patients with sickle cell disease (SCD). Because rates of disease-free survival are highest with human-leukocyte-antigen-(HLA)-matched siblings, the paucity of suitable donors has limited its use. Hundreds of cases of HLA-matched embryo selection have been reported using in-vitro fertilization (IVF) combined with pre-implantation genetic diagnosis (PGD) f… Show more
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