Abstract:The exposome is a complex scientific field that has enjoyed consistent growth over the last two decades, defined as the composite of every exposure to which an individual is subjected from conception to death. The study of the exposome requires consideration of both the nature of those exposures and their changes over time, and as such necessitates high quality data and software solutions. As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way. Thu… Show more
“…The study of the exposome requires consideration of both the co-exposures and their changes over time, and as such requires high-quality data and software solutions combining precision immunology tools with the opportunity offered by major advances in data science. [167][168][169][170][171][172] As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way. Thus, an approach to assist with clear definitions and a structured framework is needed for the wider scientific community and for public communication.…”
Section: Gaps In Knowledge and Recommendations For Future Research An...mentioning
confidence: 99%
“…Studies on the impact of the exposome, covering all environmental exposures throughout an individual's life span, on the dysfunction of the epithelial barriers are needed to improve the understanding of epithelial barrier‐related diseases such as asthma and raise awareness of the environmental insults that pose a threat to human health. The study of the exposome requires consideration of both the co‐exposures and their changes over time, and as such requires high‐quality data and software solutions combining precision immunology tools with the opportunity offered by major advances in data science 167–172 . As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way.…”
Section: Key Guidance and Recommendationsmentioning
confidence: 99%
“…As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way. Thus, an approach to assist with clear definitions and a structured framework is needed for the wider scientific community and for public communication 168 . A more comprehensive model is the One Health approach, with a sharp focus on human, animal and environmental health interconnections.…”
Section: Key Guidance and Recommendationsmentioning
The EAACI Guidelines on the impact of short‐term exposure to outdoor pollutants on asthma‐related outcomes provide recommendations for prevention, patient care and mitigation in a framework supporting rational decisions for healthcare professionals and patients to individualize and improve asthma management and for policymakers and regulators as an evidence‐informed reference to help setting legally binding standards and goals for outdoor air quality at international, national and local levels. The Guideline was developed using the GRADE approach and evaluated outdoor pollutants referenced in the current Air Quality Guideline of the World Health Organization as single or mixed pollutants and outdoor pesticides. Short‐term exposure to all pollutants evaluated increases the risk of asthma‐related adverse outcomes, especially hospital admissions and emergency department visits (moderate certainty of evidence at specific lag days). There is limited evidence for the impact of traffic‐related air pollution and outdoor pesticides exposure as well as for the interventions to reduce emissions. Due to the quality of evidence, conditional recommendations were formulated for all pollutants and for the interventions reducing outdoor air pollution. Asthma management counselled by the current EAACI guidelines can improve asthma‐related outcomes but global measures for clean air are needed to achieve significant impact.
“…The study of the exposome requires consideration of both the co-exposures and their changes over time, and as such requires high-quality data and software solutions combining precision immunology tools with the opportunity offered by major advances in data science. [167][168][169][170][171][172] As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way. Thus, an approach to assist with clear definitions and a structured framework is needed for the wider scientific community and for public communication.…”
Section: Gaps In Knowledge and Recommendations For Future Research An...mentioning
confidence: 99%
“…Studies on the impact of the exposome, covering all environmental exposures throughout an individual's life span, on the dysfunction of the epithelial barriers are needed to improve the understanding of epithelial barrier‐related diseases such as asthma and raise awareness of the environmental insults that pose a threat to human health. The study of the exposome requires consideration of both the co‐exposures and their changes over time, and as such requires high‐quality data and software solutions combining precision immunology tools with the opportunity offered by major advances in data science 167–172 . As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way.…”
Section: Key Guidance and Recommendationsmentioning
confidence: 99%
“…As the exposome is both a broad and a recent concept, it is challenging to define or to introduce in a structured way. Thus, an approach to assist with clear definitions and a structured framework is needed for the wider scientific community and for public communication 168 . A more comprehensive model is the One Health approach, with a sharp focus on human, animal and environmental health interconnections.…”
Section: Key Guidance and Recommendationsmentioning
The EAACI Guidelines on the impact of short‐term exposure to outdoor pollutants on asthma‐related outcomes provide recommendations for prevention, patient care and mitigation in a framework supporting rational decisions for healthcare professionals and patients to individualize and improve asthma management and for policymakers and regulators as an evidence‐informed reference to help setting legally binding standards and goals for outdoor air quality at international, national and local levels. The Guideline was developed using the GRADE approach and evaluated outdoor pollutants referenced in the current Air Quality Guideline of the World Health Organization as single or mixed pollutants and outdoor pesticides. Short‐term exposure to all pollutants evaluated increases the risk of asthma‐related adverse outcomes, especially hospital admissions and emergency department visits (moderate certainty of evidence at specific lag days). There is limited evidence for the impact of traffic‐related air pollution and outdoor pesticides exposure as well as for the interventions to reduce emissions. Due to the quality of evidence, conditional recommendations were formulated for all pollutants and for the interventions reducing outdoor air pollution. Asthma management counselled by the current EAACI guidelines can improve asthma‐related outcomes but global measures for clean air are needed to achieve significant impact.
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