Major advances in population health will not occur unless we translate existing knowledge into effective multicomponent interventions, implement and maintain these in communities, and develop rigorous translational research and evaluation methods to ensure continual improvement and sustainability. We discuss challenges and offer approaches to evaluation that are key for translational research stages 3 to 5 to advance optimized adoption, implementation, and maintenance of effective and replicable multicomponent strategies. The major challenges we discuss concern (a) multiple contexts of evaluation/research, (b) complexity of packages of interventions, and (c) phases of evaluation/research questions. We suggest multiple alternative research designs that maintain rigor but accommodate these challenges and highlight the need for measurement systems. Longitudinal data collection and a standardized continuous measurement system are fundamental to the evaluation and refinement of complex multicomponent interventions. To be useful to T3-T5 translational research efforts in neighborhoods and communities, such a system would include assessments of the reach, implementation, effects on immediate outcomes, and effects of the comprehensive intervention package on more distal health outcomes.
KeywordsHealth, Well-being, Evaluation design, Complex intervention, Translational research Recent research suggests that significant improvements in the life trajectories of at-risk young people are now possible [1]. Unfortunately, actual well-being lags far behind, especially in areas of concentrated poverty, where the risk of young people developing multiple behavioral and health problems is much higher than other neighborhoods [2]. Major advances in population health will not occur unless we translate existing knowledge into effective multicomponent strategies, implement them in at-risk and underserved communities, and develop rigorous evaluation methods to ensure continual improvement. The success of translational research methods to bring about change in entire communities demands the evolution of methods that are most appropriate for the task at hand. In this paper, we present approaches to translational research stages T3-T5 [3] that advance the adoption, implementation, and maintenance of effective and replicable multicomponent interventions. We highlight experimental methods that can sharpen our understanding of the impact of complex interventions as well as each component program, policy, or practice that is implemented to support community development. These experimental methods will enable continuous quality improvement to ensure that neighborhood and community change efforts become increasingly effective and sustained over time. The methods are appropriate and applicable for research stages T3-T5 nationally and globally.Most health outcomes have Bmultiple interacting influences crossing socio-ecological levels^and require complex, multi-level strategies to foster health and well-being [4] To illustrate the need for ...