Creating coveted bioluminescence colors for simultaneous myriad-color bioimaging
Mitsuru Hattori,
Tetsuichi Wazawa,
Mariko Orioka
et al.
Abstract:Bioluminescence, an optical marker that does not require excitation by light, allows researchers to simultaneously observe multiple targets, each exhibiting a different color. Notably, the colors of the bioluminescent proteins must sufficiently vary to enable simultaneous detection. Here, we aimed to introduce a method that can be used to expand the color variation by tuning dual-acceptor bioluminescence resonance energy transfer (BRET). Using this approach, we could visualize multiple targets with up to 20 co… Show more
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