Creating Computer Classrooms

Ellis, Margaret

doi:10.1177/107621758300600605

Cited by 9 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even the Wt Ki-ras transfectants exhibiting no increased level of GTP-bound Ras showed an elevated activation of this pathway. As this pathway is important for the oncogenic transformation process, this result is consistent with the morphological changes of the Ki-ras transfectants expressing a transformed phenotype as demonstrated by the spindle-shaped structure [8]. Another characteristics of transformation is the anchorage-independent growth of the G12V Ki-Ras mutant, which might be due to either increased activated Ras-GTP levels or to a specific feature of the Ras codon 12 mutation.…”

Section: Discussionsupporting

confidence: 82%

“…This is in line with results of Guerrero and coworkers [29], demonstrating a higher predisposition of codon 12-mutated fibroblasts to anchorageindependent growth. Furthermore, Ki-ras is less potent in mediating transformation than Ha-ras in fibroblasts [45], which might be explained by the relative instability of the Ki-Ras 4B protein when compared to other Ras family members [8]. Although the oncogenic Ras protein exerts effects on the gene transcription level, the relationships between signaling pathways downstream of ras, the effects of different ras mutations on the regulated genes and their contributions to malignancy are, as yet, only poorly understood at the transcriptome level and even less is known at the proteome level.…”

Section: Discussionmentioning

confidence: 99%

“…The Haras and Ki-ras genes were originally identified in Harvey [3] and Kirsten [4] ras virus-induced sarcomas of the rat, whereas the N-ras gene was first identified in neuroblastomas [5]. The Ki-ras gene encodes two protein isoforms Ki-Ras 4A and 4B that result from alternative splicing of the fourth exon [6][7][8][9]. All different ras genes code for proteins of a molecular weight of approximately 21 kDa (p21ras) and these proteins contain a covalently bound farnesyl residue [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Ki‐ras‐driven oncogenic transformation on the protein network of murine fibroblasts

et al. 2007

View full text Add to dashboard Cite

Ki-ras gene mutations that specifically occur in codons 12, 13 and 61 are involved in the carcinogenesis of acute myeloid leukemia, melanoma and different carcinomas. In order to define potential mutation-specific therapeutic targets, stable transfectants of NIH3T3 cells carrying different Ki-ras4B gene mutations were generated. Wild type Ki-ras transformants, mock transfectants and parental cells served as controls. These in vitro model systems were systematically analyzed for their protein expression pattern using two-dimensional gel electrophoresis followed by mass spectrometry and/or protein sequencing. Using this approach, a number of target molecules that are differentially but coordinately expressed in the ras transfectants were identified next to other proteins that exhibit a distinct regulation pattern in the different cell lines analyzed. The differentially expressed proteins predominantly belong to the families of cytoskeletal proteins, heat shock proteins, annexins, metabolic enzymes and oxidoreductases. Their validation was assessed by real-time quantitative RT-PCR and/or Western blot analysis. Our results suggest that the Ki-ras-transformed cells represent a powerful tool to study Ki-ras gene mutation-driven protein expression profiles. In addition, this approach allows the discovery of ras-associated cellular mechanisms, which might lead to the identification of physiological targets for pharmacological interventions of the treatment of Ki-ras-associated human tumors.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Ki‐ras‐driven oncogenic transformation on the protein network of murine fibroblasts

et al. 2007

View full text Add to dashboard Cite

show abstract

“…From a theoretical perspective, it may be interesting to ask whether the late-time inhomogeneities can affect the evolution of average quantities through the 'backreaction mechanism' (e.g. Buchert 2000;Ellis & Buchert 2005;Li & Schwarz 2007), rendering the exactly homogeneous and isotropic FRW models insuffi-cient. 1 This is still an open area of research; see Räsänen (2011); Buchert & Räsänen (2012) for recent reviews.…”

Section: Introductionmentioning

confidence: 99%

Seeing patterns in noise: gigaparsec-scale ‘structures’ that do not violate homogeneity

Nadathur¹

2013

Monthly Notices of the Royal Astronomical Society

View full text Add to dashboard Cite

Clowes et al. (2013) have recently reported the discovery of a Large Quasar Group (LQG), dubbed the Huge-LQG, at redshift z ∼ 1.3 in the Data Release 7 quasar catalogue of the Sloan Digital Sky Survey. On the basis of its characteristic size ∼ 500 Mpc and longest dimension > 1 Gpc, it is claimed that this structure is incompatible with large-scale homogeneity and the cosmological principle. If true, this would represent a serious challenge to the standard cosmological model. However, the homogeneity scale is an average property which is not necessarily affected by the discovery of a single large structure. I clarify this point and provide the first fractal dimension analysis of the DR7 quasar catalogue to demonstrate that it is in fact homogeneous above scales of at most 130 h −1 Mpc, which is much less than the upper limit for ΛCDM. In addition, I show that the algorithm used to identify the Huge-LQG regularly finds even larger clusters of points, extending over Gpc scales, in explicitly homogeneous simulations of a Poisson point process with the same density as the quasar catalogue. This provides a simple null test to be applied to any cluster thus found in a real catalogue, and suggests that the interpretation of LQGs as 'structures' is misleading.

show abstract

“…'Fully gridded' data were used in which all data from one day are treated, after removal of day-night differences, as pertaining to the same map time and interpolated onto a regular (4"XlO") latitudelongitude grid. Further details of instrument performance are given by Ellis et al (1973) and Barnett et al (1975a), and details of the analysis method in Oxford University (1976). In addition daily analyses of the height of the 200 mb surface have been provided by the Commonwealth Bureau of Meteorology in Melbourne.…”

Section: (B) T H E Datamentioning

confidence: 99%

A sudden warming in the middle atmosphere of the southern hemisphere

Al-Ajmi

Harwood

Miles

1985

Quart J Royal Meteoro Soc

View full text Add to dashboard Cite

This paper presents a case study of a wave‐mean flow interaction, or minor warming, near the southern hemisphere stratopause for 15‐30 July 1974. the analysis is based mainly on data from the selective chopper radiometer carried by Nimbus 5. A deceleration of the zonal mean wind of 70 m s‐1 from 20 to 25 July is observed in middle latitudes at 0.5 mb, with an acceleration further south. the polar vortex is, however, not disrupted. Eliassen‐Palm cross‐sections are presented for the event and a good correlation found between the E‐P flux convergence and the deceleration. the channelling of the E‐P fluxes from the tropopause to the convergent region is in broad agreement with the distribution of refractive index but there is a region of E‐P flux divergence at high levels in polar latitudes suggesting a source of wave activity there. The residual circulation is calculated both from the momentum budget and from an omega equation, both methods diagnosing a region of modest equatorward flow near the region of E‐P flux divergence embedded in the stronger poleward flow elsewhere. Maps of potential vorticity on the isentropic surface of 0 = 1640 K are presented and the evolving pattern related to zonal mean and isobaric descriptions. the event is shown to be associated with an incursion of low latitude air into middle latitudes with a corresponding irreversible mixing of potential vorticity reminiscent of the ‘wave breaking’ in northern hemisphere events reported by McIntyre and Palmer (J. At. Ter. Ph., 46, 825), but of much smaller amplitude.

show abstract

Creating Computer Classrooms

Cited by 9 publications

References 0 publications

Influence of Ki‐ras‐driven oncogenic transformation on the protein network of murine fibroblasts

Influence of Ki‐ras‐driven oncogenic transformation on the protein network of murine fibroblasts

Seeing patterns in noise: gigaparsec-scale ‘structures’ that do not violate homogeneity

A sudden warming in the middle atmosphere of the southern hemisphere

Contact Info

Product

Resources

About