Creating a tissue mimicking phantom appropriate for relaxometry, diffusion imaging and ultrasound elastography

Portakal, Z.G.; Phillips, Jonathan; Richards, Caryl E; Spezi, Emiliano; Garcia, Leo; Perrett, T.; Lewis, Donna; Tunçel, Nina

doi:10.1016/j.ejmp.2016.07.741

Cited by 2 publications

(3 citation statements)

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“…In addition to these test-tube size gels we also prepared a larger cylindrical agar hydrogel phantom consisting of a glass jar with six gel layers with varying concentrations of agar agar ranging from 0.25 g to 1.25 g per 60 ml of deionized water slightly doped with manganese chloride to reduce the T 1 relaxation times. Agarose, agar agar and carageenan gels were chosen due to their tissuemimicking properties [12,13].…”

Section: A Phantom Preparationmentioning

confidence: 99%

“…Ref. [8] found that UDD outperformed CPMG in preserving electron spin coherence in irradiated malonic acid crystals at a wide range of temperatures, while CPMG outperformed UDD for a qubit consisting of a 13 C nuclear spin coupled to a proton spin bath with a close-to-Gaussian spectral density distribution [9]. One of the applications suggested for UDD is contrast enhancement in MRI.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of CPMG and Uhrig Dynamic Decoupling (UDD) for tissue refocusing in MRI

Schirmer,

Phillips

2017

Preprint

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Two different dynamic decoupling strategies, the classic CPMG and the more recently proposed UDD protocol are compared in the context of magnetic resonance imaging (MRI). Both sequences were implemented on a 3T human MRI system and relaxometry was performed for a variety of tissue-mimicking agarose gels. We find that CPMG provides moderately better decoupling than UDD. The results are consistent with experimental noise spectra obtained from in vivo spectroscopy results, which suggest that the type of noise spectra obtained would favor CPMG. Theoretical coherence pathway analysis further suggests that UDD is more susceptible to systematic errors due to static magnetic and radio-frequency field inhomogeneity or imperfect excitation and refocusing pulse profiles.

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Section: A Phantom Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of CPMG and Uhrig Dynamic Decoupling (UDD) for tissue refocusing in MRI

Schirmer,

Phillips

2017

Preprint

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“…Portakal et al [24] aimed to fabricate tissue-equivalent for relaxometry, non-Gaussian diffusion imaging, and ultrasound elastography. They compared parameters for cancer patients such as prostate condition.…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of tissue-like phantoms for use in biomedical imaging.

Ntombela

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The continuous need for tissue-like samples to understand biological systems and the development of new diagnostic and therapeutic applications has led to the adoption of tissue models using potential materials. This work presents a low-cost method for manufacturing PVAslime glue-based phantoms to replicate diseased and healthy biological tissues’ optical, mechanical, and structural properties. The deformable phantoms with complex geometries are vital to model tissues’ anatomic shapes and chemical composition. Absorption and scattering properties were set by adding black India ink and aluminium oxide (Al2O3) particles in varying quantities to obtain slime phantom tissues with optical properties of the brain, malignant brain tumour, lung carcinoma, and post-menopausal uterus. The phantom properties were characterized and validated using a He-Ne laser emitting at 532 nm and 630 nm wavelengths propagated through various thicknesses of the fabricated phantom. The incident and transmitted intensity were measured to determine the absorption coefficient (a) and scattering coefficient (s). Furthermore, the effective attenuation coefficient (eff ) and penetration depth () were deduced from the reduced scattering coefficient (0s) and the anisotropy factor (g) obtained through the scattering phase function and Wolfram Mathematica. The anisotropy factor demonstrated a forward scatter, typical of strongly scattering media as real tissues. Such geometrically and optically realistic phantoms would function as effective tools for developing techniques in diagnostic and therapeutic applications such as laser ablation and PDT cancer treatment.

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Creating a tissue mimicking phantom appropriate for relaxometry, diffusion imaging and ultrasound elastography

Cited by 2 publications

References 0 publications

Comparison of CPMG and Uhrig Dynamic Decoupling (UDD) for tissue refocusing in MRI

Comparison of CPMG and Uhrig Dynamic Decoupling (UDD) for tissue refocusing in MRI

Design and fabrication of tissue-like phantoms for use in biomedical imaging.

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