Creating a Reactive Enediyne by Using Visible Light: Photocontrol of the Bergman Cyclization

Sud, David; Wigglesworth, Tony J.; Branda, Neil R.

doi:10.1002/anie.200703034

Cited by 79 publications

(40 citation statements)

References 38 publications

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“…568 reaction with a dienophile to generate diarylethene derivatives 314a and 315a, which cyclize upon irradiation with UV light. The photogenerated 314b and 315b can be stably isolated and become inactive to the retro-Diels−Alder reaction.…”

Section: Chemical Reactivity and Bioactivitymentioning

confidence: 99%

Photochromism of Diarylethene Molecules and Crystals: Memories, Switches, and Actuators

et al. 2014

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Section: Chemical Reactivity and Bioactivitymentioning

confidence: 99%

Photochromism of Diarylethene Molecules and Crystals: Memories, Switches, and Actuators

et al. 2014

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“…In the last few years, the Branda's group has pioneered the use of UCNPs to remotely control the photochemical response of dithienylethenes (DTEs), a class of photoswitchable molecules, which can reversibly interchange between two structural and electronic isomers upon UV and visible light (see Figure ). Furthermore, the high stability of DTEs and the durability of their photochemical behavior assure their usage for several cycles—an ideal feature for application in optical data storage, photorelease, and PDT …”

Section: Harvesting and Emitting Light With Inorganic Nanoparticlesmentioning

confidence: 99%

Light Harvesting and Photoemission by Nanoparticles for Photodynamic Therapy

Arguinzoniz

Ruggiero

Habtemariam

et al. 2013

Part & Part Syst Charact

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This review provides an overview of recent efforts to utilize light harvesting and photoemission by nanoparticles (NPs) for photodynamic therapy (PDT) applications. In particular, it focuses on the recent use of quantum dots (QDs) and upconverting nanophosphors (UCNPs), which over the past decade have captivated considerable interest in biomedical research as new classes of fluorescent probes for in vivo biomolecular and cellular imaging. Increasingly, the unique properties of QDs and UCNPs are becoming the focus of attention in PDT as an emerging cancer treatment modality where a photosensitizer molecule (PS) exposed to light of a wavelength matching its absorption spectrum mediates cytotoxic effects. An overview of the processes and approaches that have been used to induce and optimize photoinduced energy and charge transfer processes and generation of different cytotoxic species ranging from reactive oxygen species to inorganic metal‐based drugs using these NPs, as well as for their targeted delivery in a cell‐ or tissue‐specific manner is presented. The main challenge for nanomaterials entering mainstream clinical practice is understanding and overcoming their toxicity. Hence, some of the known mechanisms by which QDs and UCNPs can cause unwanted toxicity are briefly reviewed, as well as how they can be minimized.

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“…By taking advantage of visible-light molecular photoswitch, Sud et al [73] synthesized some thiophene-containing enediynes (at ene position) for BC. Lowmolecular-weight organic gelator-based, and amide-functionalized (phenylethynyl)thiophenes [74] were synthesized which were capable of immobilizing a variety of organic solvents to form stable organogels.…”

Section: 2mentioning

confidence: 99%

Recent Developments in Enediyne Chemistry

Joshi

Rawat

2012

Chemistry & Biodiversity

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The enediynes are known for highly potent anticancer, antimicrobial, as well as cytotoxic activities. The discovery of enediynes from natural sources was achieved in late 1980s. They are presently of high interest, because they exert their biological action due to their ability to form a diradical, which abstracts H-atoms from the DNA backbone, thus causing cell death. Nowadays, the major works are dedicated to the syntheses of enediynes. This review covers recent developments in enediyne chemistry of the last few decades. It is subdivided in six chapters dealing with the discussion of the chemistry and biological significances of enediynes, and the factors responsible for a better activation of enediynes and potent biological evaluations.

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Creating a Reactive Enediyne by Using Visible Light: Photocontrol of the Bergman Cyclization

Cited by 79 publications

References 38 publications

Photochromism of Diarylethene Molecules and Crystals: Memories, Switches, and Actuators

Photochromism of Diarylethene Molecules and Crystals: Memories, Switches, and Actuators

Light Harvesting and Photoemission by Nanoparticles for Photodynamic Therapy

Recent Developments in Enediyne Chemistry

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