Formal training in how to mentor is not generally provided to students, postdoctoral fellows, or junior faculty. We provide here a framework to develop as a mentor, using the GREAT Model. This includes Giving opportunities and opening doors; Reaching out to help students identify their strengths and reach their goals; Encouraging them by serving as a positive example; Advise each mentee as an individual; and Training them for independent thinking. In this personal view, we expand on each of these steps to illustrate how to develop a personalized mentoring style of your own. By combining these approaches, you as a mentor can work with your mentees to develop an effective and productive mentoring relationship.