Creatine Phosphokinase and Malate Dehydrogenase Isozymes in Heart Muscle of Sudden Death Cases

Abstract

-CPK and MDK isozyme patterns of the heart muscle in cases of sudden death were studied to investigate the relationship between their changes and the causes of death . In most of death cases from violence, asphyxia, natural disease and poisoning, the percentage of CPK-MB was about 23-34% of the total CPK, and that of MDHm was about 35-50% of the total MDH. In a few death cases of coronary sclerosis and hypertrophy of the heart, the percentages of CPK-MB and MDHm decreased. The percentages of CPK-MB and MDHm in neonates were less than those in adults and they were about 7-15% and 25-34% of the total CPK and MDH, respectively. In more than half of the cases of both cardiac death from unknown cause and cot death, the average percentages of CPK-MB and MDHm decreased significantly.

Experimental model of sudden cardiac death from unexplained cause.

“…These changes of isozyme fractions have been investigated in the human heart muscle of sudden death cases (Suzuki et al 1978(Suzuki et al , 1980. In the experimental animals, the changes of these isozyme patterns except that of MDH seemed to be almost identical with the results obtained in the human heart muscle of sudden cardiac death cases from unexplained cause.…”

“…Electropholetic analysis of each isozyme was made after our previous papers (Suzuki et al 1978(Suzuki et al , 1980.…”