Creatine Phosphokinase Activity: A Study of Normal and Abnormal Levels

Savignano, Thomas; Hanok, Albert; Kuo, Jeremiah

doi:10.1093/ajcp/51.1.76

Cited by 31 publications

(5 citation statements)

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“…Muscle injury during surgical procedures causes an increase in CK level [ 15 , 16 , 17 ], and elevated CK activity after spinal surgery was reported in some of the studies [ 18 , 19 , 20 ]. In our study, mean CK level on the first postoperative day was higher in the conventional group than in the splitting group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Spinous Process-Splitting Laminectomy versus Conventional Laminectomy for Lumbar Spinal Stenosis

et al. 2014

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Study DesignSeventy-five patients who had been treated for lumbar spinal stenosis (LSS) were reviewed retrospectively.PurposeInvasion into the paravertebral muscle can cause major problems after laminectomy for LSS. To address these problems, we performed spinous process-splitting laminectomy. We present a comparative study of decompression of LSS using 2 approaches.Overview of LiteratureThere are no other study has investigated the lumbar spinal instability after spinous process-splitting laminectomy.MethodsThis study included 75 patients who underwent laminectomy for the treatment of LSS and who were observed through follow-ups for more than 2 years. Fifty-five patients underwent spinous process-splitting laminectomy (splitting group) and 20 patients underwent conventional laminectomy (conventional group). We evaluated the clinical and radiographic results of each surgical procedure.ResultsJapanese Orthopaedic Association score improved significantly in both groups two years postoperatively. The following values were all significantly lower, as shown with p-values, in the splitting group compared to the conventional group: average operating time (p=0.002), postoperative C-reactive protein level (p=0.006), the mean postoperative number of days until returning to normal body temperature (p=0.047), and the mean change in angulation 2 years postoperatively (p=0.007). The adjacent segment degeneration occurred in 6 patients (10.9%) in the splitting group and 11 patients (55.0%) in the conventional group.ConclusionsIn this study, the spinous process-splitting laminectomy was shown to be less invasive and more stable for patients with LSS, compared to the conventional laminectomy.

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Section: Discussionmentioning

confidence: 99%

Comparison of Spinous Process-Splitting Laminectomy versus Conventional Laminectomy for Lumbar Spinal Stenosis

et al. 2014

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“…The latter collection method may have affected the poststudy (2007) values of some blood parameters (White and Cook 1974). For example, cardiac puncture of a dead animal tends to yield higher values for CPK, potassium, and phosphorus than venipuncture of a live animal, and trauma associated with lethal shooting also can elevate these parameters (Savignano et al 1969, Seal et al 1981, Latimer et al 2003). Creatinine phosphokinase, potassium, and phosphorus were the only blood‐chemistry parameters in our study with values outside the normal ranges for adult white‐tailed deer.…”

Section: Discussionmentioning

confidence: 99%

Health effects of GnRH immunocontraception of wild white‐tailed deer in New Jersey

Gionfriddo

DeNicola²,

Miller

et al. 2011

Wildlife Society Bulletin

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We evaluated the health effects of GonaCon TM Immunocontraceptive Vaccine in individual white-tailed deer (Odocoileus virginianus) on a fully fenced corporate office campus in suburban New Jersey, USA. We captured and vaccinated adult females, fawns of both sexes, and yearling and adult males, and evaluated their health status through field and necropsy observations, assessment of blood chemistry, and histopathological examination of selected tissues. One 1.0-mL intramuscular injection of vaccine was delivered by hand to the hind limb of each GonaCon-treated deer. Control deer received sham injections (ad F) or no injections (yearling and ad M). Mean body-condition scores of GonaCon-treated adult females and males were greater than those of corresponding control groups. No evidence of limping or impaired mobility was noted in study deer during the 2-year study. No adverse effects of vaccination were detected in major organs, organ systems, body condition, fat deposits, or blood chemistry. Injection-site lesions (granulomatous nodules and sterile abscesses) occurred in the deep hind-limb musculature of >85% of GonaCon-treated and sham-injected deer but were not detectable externally. Reactions at injection sites and in lymph nodes were typical responses to injection of vaccines formulated as water-in-oil emulsions, especially those, like GonaCon, that contain mycobacteria. The formation of injection-site lesions may be a necessary component of the immune response that causes infertility in treated animals. Natural resource managers who use GonaCon to manage deer in settings such as developed areas and public parks will ultimately determine its value and applicability. ß

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“…Muscle injury during surgical procedures can cause an increase in CK levels [ 12 13 14 ] with some reports indicating increased CK activity after spinal surgery [ 15 16 17 ]. In our study, the mean CK level on postoperative day 1 was low, and no statistically significant differences were observed between the LT and TL groups ( p =0.360).…”

Section: Discussionmentioning

confidence: 99%

Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors

et al. 2015

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Study DesignRetrospective chart review.PurposeA comparison of mini open foraminotomy (MOF) for cervical radiculopathy using either large tubular (LT) or TrimLine (TL) retractors.Overview of LiteraturePosterior foraminotomy relieves compression of the cervical nerve root in radiculopathy patients. However, invasion of the paravertebral muscle may cause major problems in these patients. To address these problems, we performed MOF.MethodsTwenty cervical radiculopathy patients (16 male and 4 female) who underwent MOF between May 2004 and August 2011 were assigned to LT and TL groups. Each group contained 10 subjects. Surgical and clinical outcomes were compared.ResultsThe average operating time in the TL group was significantly shorter than that in the LT group. The final follow-up mean neck disability indices significantly improved compared to the preoperative values (LT group, 12.0±7.8 vs. 28.0±9.4; TL group, 6.0±5.9 vs. 21.9±10). The final follow-up neck pain visual analog scale (VAS) scores also decreased significantly from the preoperative of 8.0±1.5 and 2.5±2.5 to the final follow-up values of 2.2±2.2 and 1.0±2.5 in the LT and TL groups, respectively. The recovery rate for the neck pain VAS score was 70.0±31.9 in the LT group and 87.0±32.0 in the TL group, thus suggesting no significant difference between the two groups.ConclusionsMOF with the TL retractor is an easy and safe procedure. Furthermore, the use of the TL retractor allows for a minimally invasive and effective surgical treatment of cervical radiculopathy patients.

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Creatine Phosphokinase Activity: A Study of Normal and Abnormal Levels

Cited by 31 publications

References 0 publications

Comparison of Spinous Process-Splitting Laminectomy versus Conventional Laminectomy for Lumbar Spinal Stenosis

Comparison of Spinous Process-Splitting Laminectomy versus Conventional Laminectomy for Lumbar Spinal Stenosis

Health effects of GnRH immunocontraception of wild white‐tailed deer in New Jersey

Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors

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