Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice

Yar, Razia Allah; Akbar, Atif

doi:10.1016/j.brainres.2014.11.017

Cited by 25 publications

(20 citation statements)

References 42 publications

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“…Cr supplementation has been reported to have a protective effect in neurons, myoblasts, and cardiomyocytes in culture when the cells are subjected to hypoxic and increased oxidative stressors (Adcock et al 1999(Adcock et al , 2002Balestrino et al 2002;Caretti et al 2010;Santacruz et al 2015a;Sartini et al 2012). Similar positive results have been reported in studies of the effects of Cr supplementation in animal models of neonatal hypoxia (Allah Yar et al 2015;Ellery et al 2013), and in a study with human volunteers that evaluated the Fig. 1 Schematic representation of the proposed organization of the CrT protein in the membrane.…”

Section: Introductionsupporting

confidence: 69%

Structural correlates of the creatine transporter function regulation: the undiscovered country

Santacruz

Jacobs²

2016

Amino Acids

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Creatine (Cr) and phosphocreatine constitute an energy shuttle that links ATP production in mitochondria to subcellular locations of ATP consumption. Cells in tissues that are reliant on this energy shuttle, such as myocytes and neurons, appear to have very limited ability to synthesize creatine. Therefore, these cells depend on Cr uptake across the cell membrane by a specialized creatine transporter (CrT solute carrier SLC6A8) in order to maintain intracellular creatine levels. Cr supplementation has been shown to have a beneficial effect in numerous in vitro and in vivo models, particularly in cases of oxidative stress, and is also widely used by athletes as a performance enhancement nutraceutical. Intracellular creatine content is maintained within narrow limits. However, the physiological and cellular mechanisms that mediate Cr transport during health and disease (such as cardiac failure) are not understood. In this narrative mini-review, we summarize the last three decades of research on CrT structure, function and regulation.

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Section: Introductionsupporting

confidence: 69%

Structural correlates of the creatine transporter function regulation: the undiscovered country

Santacruz

Jacobs²

2016

Amino Acids

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“…The authors suggested that given the safety record of creatine, creatine might be considered as a novel therapeutic agent for inhibition of ischemic brain injury in humans. Allah et al [142] reported that creatine monohydrate supplementation for 10 weeks reduced the infarction size and improved learning/memory following neonatal hypoxia ischemia encephalopathy in female mice. The authors concluded that creatine supplementation has the potential to improve the neuro-function following neonatal brain damage.…”

Section: Other Applications In Sport and Trainingmentioning

confidence: 99%

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

Kreider

Kalman²,

António

et al. 2017

Journal of the International Society of Sports Nutrition

487

602

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Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. In addition to athletic and exercise improvement, research has shown that creatine supplementation may enhance post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and concussion and/or spinal cord neuroprotection. Additionally, a number of clinical applications of creatine supplementation have been studied involving neurodegenerative diseases (e.g., muscular dystrophy, Parkinson’s, Huntington’s disease), diabetes, osteoarthritis, fibromyalgia, aging, brain and heart ischemia, adolescent depression, and pregnancy. These studies provide a large body of evidence that creatine can not only improve exercise performance, but can play a role in preventing and/or reducing the severity of injury, enhancing rehabilitation from injuries, and helping athletes tolerate heavy training loads. Additionally, researchers have identified a number of potentially beneficial clinical uses of creatine supplementation. These studies show that short and long-term supplementation (up to 30 g/day for 5 years) is safe and well-tolerated in healthy individuals and in a number of patient populations ranging from infants to the elderly. Moreover, significant health benefits may be provided by ensuring habitual low dietary creatine ingestion (e.g., 3 g/day) throughout the lifespan. The purpose of this review is to provide an update to the current literature regarding the role and safety of creatine supplementation in exercise, sport, and medicine and to update the position stand of International Society of Sports Nutrition (ISSN).

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“…Because of the high levels of creatine in the central nervous system [11], a considerable number of studies have focused on the potential neuroprotective effects of oral creatine supplementation in a variety of neurological conditions including traumatic brain injury (TBI) [12,70,71], Huntington's Disease (HD) [13,72–76], amyotrophic lateral sclerosis (ALS) [14,77–80], cerebral ischemia [15,81], and Parkinson's Disease (PD) [82–88]. One of the key focuses as to how creatine may work to reduce neuropathology in the central nervous system (CNS) has been the effect of creatine on the mitochondrial permeability transition pore [14,89].…”

Section: Creatine As a Mediator Of Neuroprotectionmentioning

confidence: 99%

“…In a study examining the effectiveness of creatine on newborn mice with cerebral hypoxia-ischemia, carotid ligation was performed at post-natal day 10 for 25 minutes [81]. At post-natal day 20 (weaning), mice were placed in either control or creatine-fed groups.…”

Section: Creatine As a Mediator Of Neuroprotectionmentioning

confidence: 99%

“…Creatine fed mice demonstrated increased performance on the rotarod and the Morris water maze (a measure of memory) (p < 0.05) as compared to control-fed animals. Additionally, mice fed a diet of 3% creatine had increased performance on both tests as compared with animals fed the 1% creatine diet [81]. Lesion size measurements were also reduced in creatine fed mice.…”

Section: Creatine As a Mediator Of Neuroprotectionmentioning

confidence: 99%

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Beyond muscles: The untapped potential of creatine

Riesberg

Weed

McDonald

et al. 2016

International Immunopharmacology

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Creatine is widely used by both elite and recreational athletes as an ergogenic aid to enhance anaerobic exercise performance. Older individuals also use creatine to prevent sarcopenia and, accordingly, may have therapeutic benefits for muscle wasting diseases. Although the effect of creatine on the musculoskeletal system has been extensively studied, less attention has been paid to its potential effects on other physiological systems. Because there is a significant pool of creatine in the brain, the utility of creatine supplementation has been examined in vitro as well as in vivo in both animal models of neurological disorders and in humans. While the data are preliminary, there is evidence to suggest that individuals with certain neurological conditions may benefit from exogenous creatine supplementation if treatment protocols can be optimized. A small number of studies that have examined the impact of creatine on the immune system have shown an alteration in soluble mediator production and the expression of molecules involved in recognizing infections, specifically toll-like receptors. Future investigations evaluating the total impact of creatine supplementation are required to better understand the benefits and risks of creatine use, particularly since there is increasing evidence that creatine may have a regulatory impact on the immune system.

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Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice

Cited by 25 publications

References 42 publications

Structural correlates of the creatine transporter function regulation: the undiscovered country

Structural correlates of the creatine transporter function regulation: the undiscovered country

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

Beyond muscles: The untapped potential of creatine

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