Creatine kinase‐myocardial band for chest pain and suspected acute coronary syndrome

Trost, Jeff; Feldman, Leonard

doi:10.1002/jhm.2384

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Once the cornerstone of AMI diagnosis, CK-MB has not yet been eliminated from practice despite considerable evidence supporting cTn as the preferred biomarker . Data published after distribution of the ACC/ESC/AHA recommendations show the these clinical practice guidelines have not succeeded in refining practice.…”

Section: Introductionmentioning

confidence: 99%

“…This retention of CK-MB has been attributed to clinicians’ reluctance to rely on cTn in certain clinical situations, as well as clinician familiarity . In 2010, a study coauthored by 7 large academic medical centers labeled CK-MB as 1 of 10 tests that no longer provide value, and a growing number of medical centers have abandoned use of CK-MB .…”

Section: Introductionmentioning

confidence: 99%

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Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome

et al. 2017

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“…CK-MB levels were also associated with relapse in our study, with only a few previous cases having reported its increase in AOSD patients 23 . CK-MB levels may be elevated due to acute or chronic muscle injury even in patients with chronic renal failure 24 . The high levels of CK-MB in AOSD patients may indicate the involvement of muscles, which may also explain its elevated levels in patients who relapse.…”

Section: Discussionmentioning

confidence: 99%

The risk of relapse for adult-onset Still’s disease: A retrospective study of 56 patients

Li,

Tang,

Ying

et al. 2024

Preprint

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Objective: Adult-onset Still’s disease (AOSD) is a multisystem autoinflammatory disorder characterized by a high spiking fever, arthralgia or arthritis, skin rash, leukocytosis, and hyperferritinemia. The relapse rate is high, from 40% to 50%. Our objective was to retrospectively analyze the risk of relapse for AOSD. Methods: Retrospective data of patients diagnosed with AOSD in our institute during 2013-2018 were analyzed. The diagnoses were based on the Yamaguchi criteria for AOSD. All long-term follow-up data were collected from medical records and phone calls. Results: In total, 56 patients with AOSD were included in this study. The mean age of the patients was 39.2 ± 14.2 years, and 37 patients (66.1%) were female. Twenty-three patients (41.1%) had experienced at least one relapse of AOSD. The factors associated with relapse were increased levels of lactic dehydrogenase (LDH) (OR = 1.003, P = 0.044) and creatine kinase-myocardial band (CK-MB) (OR = 1.111, P = 0.032). Conclusion: AOSD patients with elevated serum levels of LDH and CK-MB were more likely to have relapses, these prognostic factors may be helpful for the clinical management of AOSD patients.

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A myocardialis necrosis mértékének vizsgálata eltérő supraventricularis szívritmuszavarok rádiófrekvenciás katéterablatiós kezelését követően

et al. 2019

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Introduction: Levels of cardiac necroenzymes, high-sensitive troponin (hsTnT) and creatine kinase muscle-brain (CKMB) increase as a result of a myocardial damage following catheter ablation. Aim: To analyze the mid-term alteration of hsTnT and CKMB levels following radiofrequency ablation (RFCA) for atrial fibrillation (AF), atrial flutter (AFlu), AV-nodal reentry tachycardia (AVNRT) and electrophysiological studies (EPS) without ablation. Method: Patients undergoing RFCA for various indications and EPS were consecutively enrolled in our prospective study. Concentrations of hsTnT and CKMB were measured from serial blood samples directly before and after the procedure, 4 and 20 hours later and at 3 months follow-up. Results: Forty-seven patients (10 EPS, 12 AVNRT, 13 AFlu, 12 AF) with mean age of 55 ± 13 were included. hsTnT levels increased significantly in all groups after the procedures, while CKMB changed only in the AF group. hsTnT exceeded the reference value in all patients with ablation and in 80% of patients with EPS 4 hours post-ablation. Peak average hsTnT levels for EPS, AVNRT, AFlu were 24 ± 11, 260 ± 218 and 541 ± 233 ng/L, respectively. The highest hsTnT level was measured in the AF group (799 ± 433 ng/L). We found a positive correlation between hsTnT levels and ablation time after RFCA. Conclusions: The hsTnT levels significantly change after EPS and RFCA, in all patients who underwent ablation, and in 80% of those with EPS had hsTnT positivity in the early post-procedural phase. hsTnT levels depended significantly on the type of the subgroups and correlated with the ablation time. Awareness of those observations is essential to correctly interpret elevated hsTnT levels following RFCA. Orv Hetil. 2019; 160(14): 540–548.

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Creatine kinase‐myocardial band for chest pain and suspected acute coronary syndrome

Cited by 5 publications

References 21 publications

Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome

Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome

The risk of relapse for adult-onset Still’s disease: A retrospective study of 56 patients

A myocardialis necrosis mértékének vizsgálata eltérő supraventricularis szívritmuszavarok rádiófrekvenciás katéterablatiós kezelését követően

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