Creatine kinase MB (CK-MB) in benign paroxysmal vertigo of childhood: A new diagnostic marker

Rödöö, Peo; Hellberg, Dan

doi:10.1016/j.jpeds.2004.10.062

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…It is therefore necessary to explore laboratory markers as tools for achieving the quicker and more accurate diagnosis of BPPV. Various laboratory markers, such as neutrophillymphocyte ratios; serum vitamin D, C-reactive protein, DD dimer, fibrinogen, uric acid, and creatine kinase levels; or myocardial type and bone mineral density, have been investigated for the differential diagnosis and prediction of BPPV attacks, but some of these markers show no significant variation and may have no clinical application value (25)(26)(27)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Wu¹,

Wei²,

Lu³

et al. 2020

Front. Neurol.

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Objective: Otolin-1, a main specific otoconia matrix protein, passes through the labyrinth-blood barrier and is detectable in peripheral blood. Serum otolin-1 levels differ between patients with benign paroxysmal positional vertigo (BPPV) and healthy controls and are significantly age-related, increasing in healthy controls with age, suggesting that serum otolin-1 levels reflect otolith status. The aim of this study was to determine whether otolin-1 levels change during vertigo episodes in patients with BPPV and whether any change is specific and sensitive enough for BPPV episodes. Method: Patients diagnosed with de novo idiopathic BPPV during an acute episode were included in the study from May 2017 to May 2018. Blood samples were drawn before patients were treated with canalith-repositioning maneuvers. Serum otolin-1 levels were compared between 78 patients and 121 age-and sex-matched healthy individuals. Results: There were no significant differences between the groups in the age distribution, sex ratio, body mass index, clinical history, routine blood parameters, or total protein, albumin, uric acid, creatinine, blood urea nitrogen and lipid profiles (P > 0.05). Serum levels of otolin-1 were significantly higher in BPPV patients than in healthy controls (P < 0.001). Receiver operating characteristic analysis revealed that a serum otolin-1 value of 299.45 pg/ml was the optimal cutoff value to discriminate patients with BPPV from healthy controls (area under the curve 0.757, 95% CI 0.687∼0.826) with a sensitivity of 67.9% and a specificity of 72.7%. Conclusion: Serum levels of otolin-1 may be a potential biomarker for BPPV episodes.

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Section: Discussionmentioning

confidence: 99%

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Wu¹,

Wei²,

Lu³

et al. 2020

Front. Neurol.

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“…The patients who had normal troponin-I values were evaluated for our study. Rödöö and Hellberg observed an increase in CK-MB levels in childhood benign paroxysmal vertigo and suggested that this might be associated with benign paroxysmal vertigo muscle activity and that CM-MB might be a diagnostic marker in benign paroxysmal vertigo 9 . Although CK-MB levels in our study were higher in some cases at time of attack than before attack, the difference was not statistically significant.…”

Section: Secretion Begins Approximately 2-4 H Following Amimentioning

confidence: 98%

“…Rödöö and Hellberg investigated the CK-MB levels in children population and they suggested that CK-MB might be a diagnostic marker in benign paroxysmal vertigo 9 . There are no laboratory tests used in the diagnosis of BPPV.…”

Section: Introductionmentioning

confidence: 99%

Can CK-MB be used as a marker in benign paroxysmal positional vertigo attack?

Torun

Yalçın

Özkan

2016

The International Tinnitus Journal

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Objectives: Benign paroxysmal positional vertigo (BPPV) is one of the main causes of vertigo. More than 90% of cases of positional vertigo and nystagmus can be associated with BPPV. There is no known specific laboratory test for BPPV. Because of the possible muscle activity in BPPV (especially result of nause, vomiting and increasing heart rate) we thought the CK-MB levels may change in this situation. The purpose of this study was to investigate the relation between serum CK-MB levels and BPPV and attacks. Materials and Methods: The medical records of 35 patients with BPPV presenting to our clinic between November 2014 and November 2015 were investigated retrospectively. Thirty-two control patients with no vertigo, muscular or cardiac disease and with measured CK-MB levels were randomized into a control group. Both groups' existing CK-MB levels were obtained from the patient records. CK-MB values measured before BPPV attack from 11 patients in the patient group were also recorded. Results: The patient and control groups were similar in terms of demographic parameters. CK-MB values at time of attack in the patient group ranged between 5.4 and 38.9

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“…2,8 Macro-CK has additionally been seen in children 3 in association with myocardial damage. Rödöö,9 further described a paediatric case series of creatine kinase abnormalities in children with benign paroxysmal vertigo however there were no investigations done for macro-CK.…”

Section: 2mentioning

confidence: 99%

A case of spuriously high CK-MB: Contemplate beyond cardiac

Abdul¹,

Omar²,

Nayak³

et al. 2017

AMJ

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Creatine kinase-MB (CK-MB) is a widely tested enzyme in cardiac disease and thus has important clinical implications.We relate the scenario of a young patient presenting with chest pain whose CK-MB levels remained inordinately elevated despite a normal total CK level, resolution of symptoms and exclusion of coronary artery disease.Further analysis by electrophoresis revealed the presence of a rare molecular variant of creatine kinase: macro-CK type 1. While this may be a benign finding, there are sparse data demonstrating an association with non-cardiac pathologies such as malignancy, endocrinopathies, connective tissue and autoimmune diseases.Thus, after further exclusion of these associated conditions, the patient was reassured on the likely benign nature of macro-CK in this case.

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Creatine kinase MB (CK-MB) in benign paroxysmal vertigo of childhood: A new diagnostic marker

Cited by 13 publications

References 13 publications

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Can CK-MB be used as a marker in benign paroxysmal positional vertigo attack?

A case of spuriously high CK-MB: Contemplate beyond cardiac

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