Creatine Kinase Activity Weakly Correlates to Volume Completed Following Upper Body Resistance Exercise

Machado, Marco; Willardson, Jeffrey M.; Silva, Dailson P.; Frigulha, Italo C.; Koch, Alexander J.; Souza, Sérgio

doi:10.1080/02701367.2012.10599858

Cited by 10 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, following a 30 minute single leg eccentric step exercise protocol, Fredsted, Clausen (10) reported CK and maximal torque loss to be significantly lower in males compared to females. The aforementioned discrepancies may be attributed to differences in exercise volume [ 15 ] and/or different muscle architecture and tendon properties, for example in the elbow flexors compared to the knee extensors [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Muscle Damage following Maximal Eccentric Knee Extensions in Males and Females

et al. 2016

View full text Add to dashboard Cite

AimTo investigate whether there is a sex difference in exercise induced muscle damage.Materials and MethodVastus Lateralis and patella tendon properties were measured in males and females using ultrasonography. During maximal voluntary eccentric knee extensions (12 reps x 6 sets), Vastus Lateralis fascicle lengthening and maximal voluntary eccentric knee extensions torque were recorded every 10° of knee joint angle (20–90°). Isometric torque, Creatine Kinase and muscle soreness were measured pre, post, 48, 96 and 168 hours post damage as markers of exercise induced muscle damage.ResultsPatella tendon stiffness and Vastus Lateralis fascicle lengthening were significantly higher in males compared to females (p<0.05). There was no sex difference in isometric torque loss and muscle soreness post exercise induced muscle damage (p>0.05). Creatine Kinase levels post exercise induced muscle damage were higher in males compared to females (p<0.05), and remained higher when maximal voluntary eccentric knee extension torque, relative to estimated quadriceps anatomical cross sectional area, was taken as a covariate (p<0.05).ConclusionBased on isometric torque loss, there is no sex difference in exercise induced muscle damage. The higher Creatine Kinase in males could not be explained by differences in maximal voluntary eccentric knee extension torque, Vastus Lateralis fascicle lengthening and patella tendon stiffness. Further research is required to understand the significant sex differences in Creatine Kinase levels following exercise induced muscle damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Muscle Damage following Maximal Eccentric Knee Extensions in Males and Females

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Some studies [41,42] have shown a moderate positive correlation (r = 0.44) between CK-MM levels and VL. Nosaka and Clarkson [43] measured muscle volume involved in (unilateral or bilateral) strength exercise with the same VL and found similar increase in CK levels.…”

Section: Discussionmentioning

confidence: 98%

Gliclazide enhances exercise performance and recovery of muscle strength in healthy trained individuals: a randomized controlled trial

Martins,

Dipp,

Schaan

et al. 2024

Preprint

View full text Add to dashboard Cite

To examine the acute effect of gliclazide on exercise performance and recovery of muscle strength in healthy participants. We conducted a randomized, double-blind, placebo-controlled crossover clinical trial in 44 strength-trained men. They were allocated to gliclazide modified release (MR) (90mg, 8h before exercise sessions) or placebo, undergo three consecutive sessions of strength exercise (four sets, 80% of one-repetition maximum [1-RM] of bench press and free squat exercise). We evaluated total volume-load (VL) (#repetitions x 80%1-RM), range of motion (ROM), insulin and glucose levels, creatine kinase MM (CK-MM), lactate dehydrogenase (LDH), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), hemodynamic parameters, perceived pain and recovery scores. Gliclazide enhanced strength exercise performance with improvements in total VL (bench press 23.3%, p < 0.001; squats 23.2%, p < 0.001), and improved muscle recovery 24-48h post-exercise: ROM (shoulder 1.1%, p < 0.001; knee 1.6%, p = 0.004), CK-MM (–13.2%, p < 0.001), LDH (–12.8%, p < 0.001), TNF-α (–17.4%, p < 0.001), IL-6 (–5.3%, p < 0.001), pain (–17.7%, p < 0.001) and recovery scores (32.5%, p = 0.001). However, hypoglycemia events were observed in 3 participants in the gliclazide group. In conclusion, Gliclazide MR 90mg, 8h before strength exercise, produced ergogenic effects (exercise performance and muscle recovery), although hypoglycemia was observed in 7% of subjects. Registration: “www.clinicaltrials.gov”, “NCT04443777” (Primary Completion: 01/08/2020; Study Completion: 31/10/2023).

show abstract

“…While CK does moderately correlate (r = 0.45 to 0.55, p = 0.01 to 0.05) to the amount of resistance training volume performed (Machado et al, 2012), this correlation may not be indicative of how much volume can or should be performed. Specifically, the causative relationship between adaptive skeletal muscle remodelling and muscle damage is disputed (Damas et al, 2016).…”

Section: Muscle Damage Biomarkersmentioning

confidence: 88%

Methods for Regulating and Monitoring Resistance Training

Helms

Kwan

Sousa

et al. 2020

Journal of Human Kinetics

View full text Add to dashboard Cite

Individualisation can improve resistance training prescription. This is accomplished via monitoring or autoregulating training. Autoregulation adjusts variables at an individualised pace per performance, readiness, or recovery. Many autoregulation and monitoring methods exist; therefore, this review’s objective was to examine approaches intended to optimise adaptation. Up to July 2019, PubMed, Medline, SPORTDiscus, Scopus and CINAHL were searched. Only studies on methods of athlete monitoring useful for resistance-training regulation, or autoregulated training methods were included. Eleven monitoring and regulation themes emerged across 90 studies. Some physiological, performance, and perceptual measures correlated strongly (r ≥ 0.68) with resistance training performance. Testosterone, cortisol, catecholamines, cell-free DNA, jump height, throwing distance, barbell velocity, isometric and dynamic peak force, maximal voluntary isometric contractions, and sessional, repetitions in reserve-(RIR) based, and post-set Borg-scale ratings of perceived exertion (RPE) were strongly associated with training performance, respectively. Despite strong correlations, many physiological and performance methods are logistically restrictive or limited to lab-settings, such as blood markers, electromyography or kinetic measurements. Some practical performance tests such as jump height or throw distance may be useful, low-risk stand-ins for maximal strength tests. Performance-based individualisation of load progression, flexible training configurations, and intensity and volume modifications based on velocity and RIR-based RPE scores are practical, reliable and show preliminary utility for enhancing performance.

show abstract

Creatine Kinase Activity Weakly Correlates to Volume Completed Following Upper Body Resistance Exercise

Cited by 10 publications

References 24 publications

Muscle Damage following Maximal Eccentric Knee Extensions in Males and Females

Muscle Damage following Maximal Eccentric Knee Extensions in Males and Females

Gliclazide enhances exercise performance and recovery of muscle strength in healthy trained individuals: a randomized controlled trial

Methods for Regulating and Monitoring Resistance Training

Contact Info

Product

Resources

About