CRE for MAGIC (modular, agile, intensified &amp; continuous) processes

Ranade, Vivek V.; Sharma, Mrityunjay K.; Kulkarni, Amol A.

doi:10.1016/j.cej.2014.12.050

Cited by 14 publications

(17 citation statements)

References 60 publications

(43 reference statements)

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“…The design resulted in excellent mixing and offered a large area for heat transfer. The design details and details on the flow pattern of this micromixer have been previously published by Khalde et al and Ranade et al [27,28].…”

Section: Formulation Of Plga and Coumarin-6 Nanoparticlesmentioning

confidence: 99%

Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies

Dobhal

Srivastav

Dandekar

et al. 2021

J Mater Sci: Mater Med

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The work demonstrates the preparation of PLGA (PLGA 50:50, PLGA 75:25) nanoparticles, to encapsulate a hydrophobic molecule (coumarin-6), using the microreactor-based continuous process. The formulations were characterized using dynamic light scattering and transmission electron microscopy to determine their size, homogeneity, zeta potential, and surface morphology. The resulting nanoparticles were safe to the CHO cells (≈80% cell survival), at the concentration of ≤600 µg/mL and were successfully taken up by the cells, as demonstrated using confocal microscopy. Moreover, imaging flow cytometry confirmed that the nanoparticles were internalized in 73.96% of the cells. Furthermore, molecular dynamics simulation and docking studies were carried out to explore the effect of polymer chain length of PLGA and lactide vs glycolide (LA:GA) ratio on their compatibility with the coumarin-6 molecules and to study the coiling and flexibility of PLGA in the presence of coumarin-6 molecules. Flory–Huggins interaction parameter (χ) was calculated for polymer chains of varying lengths and LA:GA ratio, with respect to coumarin-6. χ parameter increased with increase in polymer chain length, which indicated superior interaction of coumarin-6 with the smaller chains. Amongst all the polymeric systems, PLGA55 exhibited the strongest interaction with coumarin-6, for all the chain lengths, possibly because of their homogeneous spatial arrangements and superior binding energy. PLGA27 showed better compatibility compared to PLGA72 and PGA, whereas PLA-based polymers exhibited the least compatibility. Analysis of the radius of gyration of the polymer chains in the polymer–coumarin-6 complexes, at the end of molecular dynamics run, exhibited that the polymer chains displayed varying coiling behavior and flexibility, depending upon the relative concentrations of the polymer and coumarin-6. Factors like intra-chain interactions, spatial arrangement, inter-chain binding energies, and polymer–coumarin-6 compatibility also influenced the coiling and flexibility of polymer chains.

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Section: Formulation Of Plga and Coumarin-6 Nanoparticlesmentioning

confidence: 99%

Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies

Dobhal

Srivastav

Dandekar

et al. 2021

J Mater Sci: Mater Med

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“…Residence time is an important time scale for designing any reactor. Residence time along with different time scales like mass transfer, mixing, heat transfer and dispersion are useful in finding the controlling step [ 86 ]. This helps in selection of the appropriate reactor device for pilot or commercial scale operations.…”

Section: Reviewmentioning

confidence: 99%

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

Shukla¹,

Kulkarni²

2017

Beilstein J. Org. Chem.

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The implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast literature in multistep synthesis, we have classified the literature and have identified the case studies based on few criteria viz. type of reaction, heating methods, processes involving in-line separation units, telescopic synthesis, processes involving in-line quenching and process with the smallest time scale of operation. This classification will cover the broader range in the multistep synthesis literature.

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“…For laminar flows, the length scales are usually reduced by realizing folding and refolding of the lamellar structure and reducing thickness of the lamellas. Some of the augmentation of mixing and other transport processes are summarized by Ranade et al 5 A variety of high shear mixers using rotor-stator flows can be used for intensifying micromixing controlled reactions (such as polyurethane reactions). A large number of innovative designs of static mixers have also been developed for intensifying mixing controlled reactions.…”

Section: ■ Strategies For Intensificationmentioning

confidence: 99%

“…There is a gradual but certain expansion of scope of research and development from microdevices to milli-or even centi-scale devices, which has considerably enhanced the potential for adoption in practice. Recently, Ranade et al 5 have described the development of MAGIC (modular, agile, intensified, and continuous) reactors and their applications for intensifying variety of reactions. They have also discussed key drivers, factors, and tools available for intensifying reactions.…”

Section: ■ Introductionmentioning

confidence: 99%

Intensifying Multiphase Reactions and Reactors: Strategies and Examples

Utikar

Ranade²

2017

ACS Sustainable Chem. Eng.

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Intensification is intrinsic to better chemical and process engineering and has always been used in practice. Multiphase reactions and reactors are ubiquitous in chemical and allied industries and are of great economic and ecological importance. There is a great scope for intensifying multiphase reactions and reactors for realizing productivity enhancements, which are crucial for sustainable manufacturing. These enhancements can be in terms of increased throughput; better yield, conversion, and selectivity; smaller environmental footprint; and intrinsically safer operations. The advances in intensified reactors especially micro-reactors and microfluidic devices have created significant awareness about intensification in recent decades. In this note, we discuss different strategies for intensifying multiphase reactions and reactors based on the published information. Variety of tools and examples are presented to showcase the potential of intensification. We have found the efforts towards intensification of multiphase reactions and reactors very rewarding academically as well as professionally. We hope that this note will further stimulate interest in this area and pave the way towards realizing next generation productivity for chemical and allied industries.

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CRE for MAGIC (modular, agile, intensified & continuous) processes

Cited by 14 publications

References 60 publications

Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies

Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

Intensifying Multiphase Reactions and Reactors: Strategies and Examples

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