Craving and Withdrawal as Core Symptoms of Alcohol Dependence

Bruijn, Carla de; Korzec, A.; Koerselman, Frank; Brink, Wim van den

doi:10.1097/01.nmd.0000131912.71344.e4

Cited by 26 publications

(24 citation statements)

References 60 publications

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“…Many individuals who are dependent on alcohol experience craving (De Bruijn, Korxec, Koerselman, & van Den Brink, 2004). A recent study suggested that alcohol craving may be a predictor of relapse (Schneekloth et al, 2012).…”

Section: Other Important Characteristics Of An Animal Model Of Alcohomentioning

confidence: 99%

The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats – Animal models of alcoholism

McBride

Rodd

Bell

et al. 2014

Alcohol

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The objective of this article is to review the literature on the utility of using the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats in studies examining high alcohol drinking in adults and adolescents, craving-like behavior, and the co-abuse of alcohol with other drugs. The P line of rats meets all of the originally proposed criteria for a suitable animal model of alcoholism. In addition, the P rat exhibits high alcohol-seeking behavior, demonstrates an alcohol deprivation effect (ADE) under relapse drinking conditions, consumes amounts of ethanol during adolescence equivalent to those consumed in adulthood, and co-abuses ethanol and nicotine. The P line also exhibits excessive binge-like alcohol drinking, attaining blood alcohol concentrations (BACs) of 200 mg% on a daily basis. The HAD replicate lines of rats have not been as extensively studied as the P rats. The HAD1,2 rats satisfy several of the criteria for an animal model of alcoholism, e.g., these rats will voluntarily consume ethanol in a free-choice situation to produce BACs between 50–200 mg%. The HAD1,2 rats also exhibit an ADE under repeated relapse conditions, and will demonstrate similar levels of ethanol intake during adolescence as seen in adults. Overall, the P and HAD1,2 rats have characteristics attributed to an early onset alcoholic, and can be used to study various aspects of alcohol use disorders.

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Section: Other Important Characteristics Of An Animal Model Of Alcohomentioning

confidence: 99%

The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats – Animal models of alcoholism

McBride

Rodd

Bell

et al. 2014

Alcohol

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show abstract

“…Alcohol-related cues, including the sight and smell of alcohol drinks, acquire conditioned incentive properties (Barker and Taylor, 2014;Field and Duka, 2002), can provoke intense craving in individuals that abuse or have lost control over alcohol (Ludwig, 1986;De Bruijn et al, 2004), and may be a predictor of relapse after abstinence (Schneekloth et al, 2012).…”

Section: Cue-controlled Alcohol-seeking Behavioral Proceduresmentioning

confidence: 99%

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

Giuliano

Goodlett

Economidou

et al. 2015

Neuropsychopharmacol

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Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioid receptor antagonist, on both voluntary alcohol-intake and alcohol-seeking behaviors. Rederived alcohol-preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana University) first received 18 sessions of 24 h home cage access to 10% alcohol and water under a 2-bottle choice procedure. They were trained subsequently to respond instrumentally for access to 15% alcohol under a second-order schedule of reinforcement, in which a prolonged period of alcohol-seeking behavior was maintained by contingent presentations of an alcohol-associated CS acting as a conditioned reinforcer. This seeking period was terminated by 20 min of free alcohol drinking access that achieved significant blood alcohol concentrations. The influence of pretreatment with either naltrexone (0.1 − 1 − 3 mg/kg) or GSK1521498 (0.1-1-3 mg/kg) before instrumental sessions was measured on both seeking and drinking behaviors, as well as on drinking in the 2-bottle choice procedure. Naltrexone and GSK1521498 dose-dependently reduced both cue-controlled alcohol seeking and alcohol intake in the instrumental context as well as alcohol intake in the choice procedure. However, GSK1521498 showed significantly greater effectiveness than naltrexone, supporting its potential use for promoting abstinence and preventing relapse in alcohol addiction.

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“…Nevertheless, craving has been linked both to poorer outcomes following treatment and greater attrition during treatment (6)(7)(8)(9). Alcohol craving is generally considered a core symptom of AUD and a strong predictor of relapse in patients with AUD (9)(10)(11)(12). Consistent with these observations, craving was the main factor related with relaps among Turkish inpatients with AUD during 12 months after inpatient treatment (13).…”

Section: Introductionmentioning

confidence: 88%

Validation study of the Turkish version of the Craving Typology Questionnaire (CTQ) in male alcohol-dependent patients

Evren¹,

Umut²,

Ağaçhanlı³

et al. 2016

Dusunen Adam

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Validation study of the Turkish version of the Craving Typology Questionnaire (CTQ) in male alcohol-dependent patients Objective: Alcohol craving is considered a core symptom of alcohol use disorder and a strong predictor of relapse in alcohol-dependent adults. The Craving Typology Questionnaire (CTQ) allows dimensional selfrating assessment of craving according to a three-pathway psychobiological model of craving (reward, relief, and obsessive craving). Aim of the present study was to evaluate psychometric properties of the Turkish version of the CTQ in a sample of inpatients and outpatients with alcohol use disorder (AUD).Method: Participants included 157 inpatients and outpatients with AUD. Participants were evaluated with the CTQ and the Obsessive-Compulsive Drinking Scale (OCDS), which includes items to evaluate both total craving and its obsessive and compulsive components.Results: The obsessive, relief, and reward craving components accounted for 27.91%, 8.17% and 7.23% of total variance, respectively. Items 7 and 8 were included in obsessive craving and item 10 was included in relief craving instead of reward craving. Obsessive craving had a Cronbach's α of 0.87, whereas the coefficients were 0.64 for relief craving and 0.42 for reward craving. Items were moderately correlated with their subscales. All types of craving were moderately correlated with OCDS and the obsessive dimension of OCDS, whereas they were mildly correlated with the compulsion dimension of OCDS.

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Craving and Withdrawal as Core Symptoms of Alcohol Dependence

Cited by 26 publications

References 60 publications

The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats – Animal models of alcoholism

The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats – Animal models of alcoholism

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

Validation study of the Turkish version of the Craving Typology Questionnaire (CTQ) in male alcohol-dependent patients

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